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11 terms

Antipsychotics

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Chlorpromazine
Typical Antipsychotic - DA receptor antagonist. Used for schizophrenia. Low potency, wide spectrum of effects, lower incidence of DA-like actions, less selective as DA receptor antagonist. Side effects: ocular opacity
Thioridazine
Typical Antipsychotic - DA receptor antagonist. Used for schizophrenia. Low potency, wide spectrum of effects, lower incidence of DA-like actions, less selective as DA receptor antagonist. POOR antiemetic. Side effects: cardiac irregularities can be fatal, ocular opacity.
Prochlorperazine
Typical Antipsychotic - DA receptor antagonist. Used for schizophrenia and antiemetic (prototype). More potent and selective as DA receptor antagonist, higher incidence of DA-type effects and narrower spectrum of side effects.
Fluphenazine
Typical Antipsychotic - DA receptor antagonist. Used for schizophrenia.
Haloperidol
Typical Antipsychotic - DA receptor antagonist (chemically different, same action). Used for schizophrenia. HIGH potency. Butyrophenone. Depot injection (IM), dosing 14-28 days.
Clozapine
Atypical Antipsychotic - DA receptor antagonist (5-HT 2A, D2). Used for schizophrenia (refractive). Lower risk for tardive dyskinesia and EPS side effects. Side effects: significant leukopenia and other blood dyscrasias, REQUIRES monitoring of blood components.
Olanzapine
Atypical Antipsychotic - DA receptor antagonist (D2 antagonist, greater affinity for D4 and 5-HT 2A-> less DA-type side effects). Used for schizophrenia (refractive).
Risperidone
Atypical Antipsychotic - DA receptor antagonist (D2 antagonist, greater affinity for D4 and 5-HT 2A -> less DA-type side effects). Used for schizophrenia (refractive). Side effects: weight gain, metabolic problems, most strongly associated with EPS.
Quetiapine
Atypical Antipsychotic - DA receptor antagonist (D2 antagonist, greater affinity for D4 and 5-HT 2A -> less DA-type side effects). Used for schizophrenia (refractive). Side effects: hypothyroidism, cataracts
Ziprasidone
Atypical Antipsychotic. Benzisoxazole. Low D2/5-HT 2A ratio, medium potency
Aripiprazole
Atypical Antipsychotic. Benzisoxazole. Medium D2/5-HT 2A ratio, high potency