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alteration of homeostasis to "point of no return" = cell death, necrosis, removal of stimuli: still no return to normal
fatty change - definition
early stage: sub-lethal damage, intracytoplasmic vaculoation bc of vacuoles of fat
fatty change pathogenesis
impaired metabolism of fatty acids thus build up of triglycerides, thus intracytoplasmic fat vacuoles
stages of fatty change
1. lipids into hepatocytes as FFA
2. FFA turned into: cholesterol, phopholipids, ketones, triglycerides
3. Triglycerides + apoproteins to make lipoproteins
4. Lipoproteins: only form triglycerides can leave hepatocytes
abnormalities in any of this causes fatty change
which cells do you mainly find fatty change
cells dependant on fat metabolism (hepatocytes)
renal tubular epithelium
gross appearance of fatty change
liver diffusely yellow, or reticular pattern if only a zone is affected
gross of coagulative
architecture of necrotic looks like normal, except for color and texture could be diff
area could be surrounded by inflammation
microscopic change in coagulative of cytoplasm
inc eosinophilia (light pink) (loss of ribosomes)
hyalinized (glassy) apperance bc loss of glycogen
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