Create an account
characteristics of CT
- specialized cells, protein fibers, ground substance
- embryonic, CT proper, specialized CT
- made from mesoderm
- mesenchyme: spindle-shaped cells that interconnect via gap junctions, few reticular fibers
- mucous: in umbilical cord, dispersed cells, supportive network for arteries and blood vessels - decreases as gestation continues
- flexible but strong due to covalent bones between collagen molecules in adjacent rows
- glycine every 3rd AA to allow flexibility
- 3 alpha chains - 42 diff. alpha chains
- whole bunch of collagen with hydrogen bonding, here it is released into cove with ends that get cleaved
- packed into fibrils
types of collagen
- made of 3 alpha chains
- 42 types of alpha chains; 28 collagens characterized
- homotrimeric v heterotrimeric
fibrillar collagen biosynthesis
- make procollagen by translation/transcription
- need vitamin C for hydroxyproline of procollagen
- enzymes in cove cut C & N terminus - middle part makes the fibers
from fibrillar collagens to fibrils
- collagen fibrils assemble from many types of fibrillar collagens
- mature fibrils associate with other proteins that help link them to their environment
collagen synthesis v. degradation
- collagen molecules produced by fibroblasts, chondrocytes, osteoblasts, pericytes, epithelial cells
- growth factors stimulate collagen synthesis (TGF-B, PDGF) by fibroblasts
- steroid hormones inhibit synthesis of collagen
- degraded through proteolytic degradation and phagocytosis
- type III collagen
- form branching patterns
- support cells of soft organs for framework
- early wound repair and replaced later by type I collagen fibers
- produced by fibroblasts, schwann cells, smooth muscle cells
- thinner than collagen but branching
- composed of elastin and fibrillin - no collagen
- glycines randomly arranged so random kinks
- in blood vessels that expand and recoil
- bind covalently via desmosine and allysine (modified AA)
- fibrillin-1 microfibrils are substrates fro assembly of elastic fibers
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together