A Cytomegalovirus (CMV) is one of the congenital neonatal TORCH infections (toxoplasmosis, other [syphilis, varicella-zoster, and parvovirus in this list], rubella, cytomegalovirus, and herpes simplex/hepatitis/HIV). CMV is the most common congenital infection. The disease-specific manifestations for CMV include microcephaly with periventricular calcifications, neonatal jaundice with direct hyperbilirubinemia, and hepatosplenomegaly. Other associated manifestations include intrauterine growth retardation, thrombocytopenia, and purpura. Disease-specific manifestations for herpes simplex virus include skin/eye/mouth vesicles, encephalitis, respiratory distress, and sepsis. Disease-specific manifestations of rubella include congenital heart lesions (patent ductus arteriosus, pulmonary artery stenosis, aortic stenosis, ventricular defects), thrombocytopenic purpura characterized by purple macular lesions ("blueberry muffin" appearance), cataracts, retinopathy, and sensorineural deafness. Disease-specific manifestations of syphilis include mucocutaneous lesions (snuffles), periostitis, osteochondritis, and hemolytic anemia.