Obvious, apparent, perceptible to the eye (adj.) or to become obvious, apparent, perceptible to the eye (verb). Also to show, make clear, or prove (verb). As a noun, a manifest is a list of people or goods aboard a plane, ship, train, etc. A manifestation is often when something "under the surface"
breaks out or becomes apparent.
Lupus is difficult to diagnose, but sometimes manifests as muscular weakness or joint pain.
The protest was a manifestation of a long-brewing discontent.