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40 terms

Digestive tract (GI) of monogastric animals

STUDY
PLAY
Prehension
taking in of feed or water
Digestion
breakdown large food molecules (CHO, proteins, lipids) into suitable products (sugars, amino acids, fatty acids) for absorption.
i. Mechanical action (chewing, grinding)
ii. Chemical action (HCL)
ii. Enzymatic action (by animal or microbes in animals)
Absorption
transfer of small molecules from the lumen of GI-tract to the circulating blood
Digestive System-Monogastric animals
Have single compartment stomach
eg. human, pigs, horses, dogs, cats or avian
Have limited ability to digest and utilize fiber (NDF) (except horses)
Digestive System-Ruminant animals
- multi-compartment stomach
eg. cows, sheep, goats, deer,..etc

- high ability to digest/utilize fibrous feeds
Monogastric digestive tract
Consist of 6-main parts:
1. Mouth
2. Esophagus
3. Stomach
4. Small Intestine (SI)
5. Large Intestine (LI)
6. Supportive organs
a. Liver
b. Pancreas
c. gall bladder
Mouth
Functions:
1. Receive feed
Lips, teeth and tongue help in prehension

2. Saliva secretion
3-paired saliva glands in the mouth
i. Parotids gland
ii. Submandibular (submaxillary) gland
iii. Sublingual gland
3. Digestion
- Mechanical (chewing)
- Enzymatic (α-amylase → starch digestion)

4. Food taste
- tasted buds
- #'s &distributions vary between animals
Composition of saliva(mouth)
99% water
-Mucus → lubrication aid for swallowing
-Bicarbonate salts (Na) → buffer to regulate pH of stomach
-Amylase enzyme in some species
Human-strong activity
Pigs- limited
Horses- not exist
Saliva Functions
1. Lubricant
2. Protection of membranes in mouth
3. Digestion (amylase)
4. Thermoregulations (dogs-panting; cats-grooming
Factors affecting saliva production
1. Feed intake
as intake increase → saliva flow ↑

2. Feed moisture content
wet feed → ↓saliva

3. Diet composition (fiber)
fiber increase chewing → saliva flow ↑

4. Health
Esophagus
Hollow muscular tube lined with mucosal cells that transport ingesta from the mouth to stomach

Peristaltic muscular contractions

Cardiac valve (sphincter) at the end of esophagus prevent ingesta from moving back.
Stomach
Size vary between species
human: 1.5 L (20% of human GI relative capacity)
Pigs: 7.9 L (30% of pigs GI relative capacity)
horses: 18.2 L (9% of horses GI relative capacity)
Functions:Stomach
1. Storage of ingested feed (control flow)
2. Reduce feed particle size through its muscular movements
3. Initiate protein digestion
4. Secretions of gastirc juices
Secretions in the stomach (gastric Juices)
1.Hydrochloric acid (HCL)
2. Pepsinogen
3. Mucus
Hydrochloric acid (HCL)
- Lowers stomach pH = 1-3

Low pH cause:
a. Initiate protein digestion (denaturation)
b. Activate a protein digestive enzyme (pepsin)
c. Kill pathogenic bacteria in ingested feeds
Pepsinogen
- inactive proteolytic enzyme
- conversion to pepsin (active proteolytic enzyme) requires HCL (low pH condition)
Mucus
- Protecting stomach wall from acid and pepsin
- Malfunction → Ulcer

No absorption of nutrients in the stomach


- Materials leaving the stomach called Chyme
Liver Functions
1.Bile synthesis
2. Site for urea formation
3. Detoxification of harmful compounds
4. Storage of CHO (glycogen) and vitamins
5. Synthesis of glucose
6. Synthesis of cholesterol and triglycerides
7. Synthesis and degradation of amino acids
Bile Synthesis(Liver Function)
- Made in the liver
- Stored in gallbladder
- Secreted bile enters duodenum (small intestine) via duct (bile duct).
Bile Function(Liver Function)
a. Emulsification of fats to facilitate lipids digestion and absorption in small intestine
b. Activate pancreatic lipase enzyme
Pancreas
Assist in CHO, proteins and lipids digestion in small intestine
Pancreatic secretions enter duodenum (small intestine) via duct
Pancreatic secretions:
1. Digestive enzymes:
2. Bicarbonate (buffer)
3. Hormones
Digestive enzymes
a. Amylase → digest starch
b. Trypsin
c. Chymotrypsin
d. Carboxypeptidase
e. Neuclease
b - e → involve in proteins digestion
f. Lipase → digest lipids
g. cholesterol esterase → digest cholesterol
Bicarbonate (buffer)
- Neutralize small intestine pH
- Enzymes require pH > 6.5 to function in small intestine (duodenum)

- Pancreatic enzymes and bicarbonate are made in pancreas → released into duodenum (small intestine) via duct.
Hormones
a. Insulin
b. Glucagon

- Released into blood
- Regulate (maintain) blood glucose level

High blood glucose → insulin release →↑ glucose uptake by cells and also increase glycogen synthesis

Low blood glucose → ↑ glucagon release →
a. breakdown glycogen to glucose
b. increase synthesis of glucose from AA
Small Intestine (SI)
The part between stomach and large intestine
-Length vary between animals
- Main site for CHO, protein and lipid digestion and nutrients absorption in monogastric animals
3 sections
of Small Intestine (SI)
1. Duodenum
2. Jejunum
3. ileum
Duodenum
- First section of SI
- Shortest section
- Main site for CHO, protein and lipid digestion
- pH = 6.0-6.5

- Digestion accomplished by secretions from:
a. Pancreas (enzymes and buffer)
b. Duodenal wall (enzymes)
c. Liver (bile)
duodenal wall secretions
-Enzymes
1. Maltase
2. Sucrase help in CHO digestion
3. Lactase

4. Aminopeptidase
5. Dipeptidase help in protein digestion
Jejunum and ileum
Jejunum = Middle section
Ileum = Last section

Jejunum & ileum are the main site for nutrients absorption (AA, glucose, FA, vit & minerals)

Walls of lower intestine are folded and lined with villi (fingerlike projections) → help in ↑ing surface area

Each villi has minute projections called microvilli → more ↑ in surface area
Absorption in SI
1. Passive diffusion
2. Facilitated diffusion
3. Active absorption
. Passive diffusion
from high to low concentration
eg. minerals, water
. Facilitated diffusion
- from high to low concentration but use carrier proteins in intestinal surface
- eg. vitamins
Active absorption:
- from low to high concentration
- requires energy and specific carrier proteins
eg. Glucose and amino acids
Large Intestine (LI)
Shorter but wider than SI.
Size vary between species
3 Sections of LI
1.Cecum
2. Colon:
3. Rectum
Cecum
- first section of LI
- Contain active bacteria similar to rumen bacteria
- Fermentation site
Monogastric animals however, don't benefit from these vitamins and bacterial protein
Colon:
Storage site
water absorption (also some minerals absorption)
No absorption of amino acids and sugars
Rectum
last section
LI functions
1. Fiber digestion
- Digestion by bacteria inhabiting the cecum
(very limited in monogastric animals except in horses)
- End-products of fermentation (VFA, B-vits, bactereial protein) have little use.

2. Absorption
- water (mainly)
- very limited absorption of nutrients (feedstuff or microbial origin)
- No AA or glucose absorption