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Pharm- GU and men's health meds
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Terms in this set (48)
what are the risks of testosterone tx for transmen?
breast and uterine cancer + liver dysfx/ elevated hematocrit
what are the risks of testosterone tx for cis men?
impotence and prostate cancer + liver dysfx/ elevated hematocrit
what is the MOA of GnRH analogs for pubertal hormone suppression for transgender youth?
-suppress gonadotropins by GnRH receptor desensitization
-initial increase in FSH and LH --> then w/ cont use = secretion is suspended
what is the MOA of GnRH antagonists?
-direct block of GnRH receptor
-rapid decrease in LH and FSH
Identify the preferred androgen blocker for feminization therapy in transgender women
Leuprolide acetate q1-6mos IM or SQ
or
Histrelin acetate q12mos implant ---> levels suppressed w/i 1mon
when should GnRH analogs be used for transgender youth?
-early pubertal youth
-use after girls/boys first exhibit tanner stage 2 (girls 9-11 and boys 10-12)
true/false
GnRH analogs are NOT reversible
false- puberty will resume
tx of choice for acute bacterial prostatitis if STI suspected + duration
ceftriaxone + doxy 14-28 days
tx of choice for chronic (>6mos) bacterial prostatitis + duration
depends on organism
-cipro
-levofloxacin
-doxy
4-12 weeks
epididymitis/orchitis tx
-cef + doxy
or
-cef + levofloxacin
PDE-5 inhibitors suffix
-afil
List the PDE-5 inhibitors (5)
Sildenafil
Tadalafil
Vardenafil
Avanafil
what are the PDE-5 inhibitors used for?
erectile dysfx
Name the PDE-5 inhibitor:
-Injectable prostaglandin
-Second line tx for ED
Alprostadil
when should PDE-5 inhibitors be dosed?
Dosed 30 min-1 hr prior to sexual activity
What is the MOA of PDE-5 inhibitors?
Inhibit inactivation of cGMP in penile tissue
-Hepatic and renal dose adjustments
-Pt on nitrate tx
-CV dz
-Sickle cell dz, myeloma, leukemia
-Retinitis pigmentosa
-Elderly w/ renal impairment
CI's to PDE-5 inhibitors
-CV: flushing
-EENT: rhinitis, sinusitis, blue/green color changes
-GI: dyspepsia, Nausea
-GU: priapism
-Flu-like symptoms
-Neuro: HA
ADRs of PDE-5 inhibitors
what are the DDI of PDE-5 inhibitors
-Nitrates
-Anti HTN
-Alpha blockers
-Macrolides, antifungals, BB, diuretics
-Inject into intracavernosum cavity
-Intraurethral pellets
Alprostadil
what is the MOA of Alprostadil
Increase cAMP → smooth muscle relaxation→ Increase arterial blood flow to corpus cavernosum
what are the ADRs of Alprostadil
-Penile pain
-Cavernosal scarring
-Priapism
what is a DDI of Alprostadil
PDE-5 inhibitors
List the (2) 5-alpha reductase inhibitors
Finasteride
Dutasteride
what are Finasteride and Dutasteride used for?
BPH
Prostate volume >30 cc on imaging or PSA > 1.5, or palpable prostate on DRE
how long does it take for finasteride to become effective?
2-6mos
what is the MOA of finasteride?
-Inhibit conversion of testosterone to dihydrotestosterone
-Suppress prostate growth
what is the BB assoc w/ 5-alpha reductase inhibitors?
pregnancy
men taking finasteride cannot do what while on the med?
donate blood while taking and for up to 1 mon after
what is a major risk of taking 5-alpha reductase inhibitors?
high-grade prostate cancer
what lab must be monitored while taking finasteride
PSA
-Postural hypoTN
-Rhinitis
-Impotence, decreased libido, gynecomastia
-Weakness
-Dizzy, somnolence
-Dyspnea
ADRs of 5-Alpha- Reductase Inhibitors
List the Non-Selective Alpha-1 Adrenoceptor Antagonists
Prazosin
Doxazosin
Terazosin
List the Selective Alpha-1 Adrenoceptor Antagonists
Alfuzosin
Tamsulosin
Silodosin
what are selective/non-selective Alpha-1 Adrenoceptor Antagonists used for?
BPH
which Alpha-1 Adrenoceptor Antagonists are "safer"?
selective
what is the MOA of Alpha-1 Adrenoceptor Antagonists?
-Smooth muscle relaxation
-Decrease obstruction of urine flow
-Effect is reversible
What are the CIs of Alpha-1 Adrenoceptor Antagonists?
-Orthostasis (esp after 1st dose)
-Floppy eye syndrome from cataract surgery
-Priapism
-Angina
which 2 Alpha-1 Adrenoceptor Antagonists require renal dosing?
alfuzosina and silodosin
Name the Alpha-1 Adrenoceptor Antagonists:
-More CNS effects; Not recommended for BPH
prazosin
-Orthostatic hypoTN
-Rhinitis
-Decreased libido
-GI distress
-Muscle and back pn
-HA, dizzy
ADRs of Alpha-1 Adrenoceptor Antagonists
list the (2) Topical (one is actually oral and also used for BPH)
Alpha-1 Adrenoceptor Antagonists
Minoxidil
Finasteride
what are the Topical
Alpha-1 Adrenoceptor Antagonists used for?
male pattern baldness
how long does it take for finasteride/minoxidil to start showing results?
2-6 mos
what is the BB for Topical
Alpha-1 Adrenoceptor Antagonists
pregnancy
what cannot be done while using Topical
Alpha-1 Adrenoceptor Antagonists?
cannot donate blood
what are the CIs of taking testosterone?
-Hypersensitivity to meds
-Breast CA in males
-Prostate CA or PSA >4
-Planning a pregnancy
-Smokers, vascular dz, polycythemia
- Men >65
-CV risk
the following are ADRs of what drugs:
-Edema, flushing, HTN, vasodilation
-Acne, alopecia, dry skin, erythema, hirsutism
-Breast tenderness, gynecomastia
-N/V/GI
-Leucopenia, clotting suppression
-Weakness
-Aggression, amnesia, HA, paresthesia, nervousness
-Pain/swelling at injection site
testosterone meds
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Verified questions
french
You are applying for a job as a server at a small French restaurant in town. You want to make sure your French sounds good, so you practice by asking these questions. Be sure to fill in the correct article, de la, du, de I', un, une, or des Vous voulez $\rule{1cm}{1pt}$ banane?
french
Solve the puzzle by figuring out the missing month. SUDOKU des mois fran$\c{c}$ais | jan. | fév. | mars | avril | mai | juin | juil. | ao$\^{u}$t | sept. | oct. | nov. | déc. | | :---: | :---: | :---: | :---: | :---: | :---: | :---: | :---: | :---: | :---: | :---: | :---: | | 1. | juin | 7. | juil. | jan. | fév. | 19. | déc. | avril | nov. | 31. | mai | | juin | jan. | juil. | 10. | mars | 16. | mai | sept. | ao$\^{u}$t | 28. | déc. | 34. | | 2. | déc. | jan. | mars | 13. | mai | nov. | fév. | 25. | juil. | avril | ao$\^{u}$t | | sept. | mars | fév. | 11. | oct. | ao$\^{u}$t | 20. | avril | juil. | 29. | mai | nov. | | 3. | oct. | juin | mai | 14. | jan. | avril | 22. | nov. | ao$\^{u}$t | fév. | 35. | | fév. | 4. | mai | juin | nov. | 17. | sept. | jan. | 26. | déc. | ao$\^{u}$t | avril | | déc. | sept. | 8. | ao$\^{u}$t | fév. | oct. | 21. | nov. | mars | mai | 32. | juil. | | mai | 5. | oct. | nóv. | 15. | déc. | mars | 23. | jan. | fév. | sept. | 36. | | nov. | avril | ao$\^{u}$t | 12. | juin | sept. | oct. | mai | 27. | mars | juil. | jan. | | ao$\^{u}$t | 6. | déc. | oct. | juil. | 18. | fév. | juin | mai | 30. | jan. | mars | | avril | mai | 9. | sept. | ao$\^{u}$t | juil. | juin | 24. | déc. | jan. | 33. | fév. |
literature
Describe the tone of the poem. How is it created?
question
The sentence may contain errors in pronoun usage. If the sentence is correct write *C* on the line provided. If a sentence is incorrect, underline the pronoun error. Then, write the correct pronoun on the line provided. Example $\underline{\text{I}}$ 1. In the morning, my brother Kele is usually more alert than $\underline{\text{me}}$. ________Sally is one student whom will be late.
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