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Signs and symptoms of Francisella Tularensis
High fever, pneumonia, headache, lymphadenopathy, granulomatous lesions
What happens in antibody activity after infection of Francisella Tularensis
IgM, IgA, and IgG persist for years after infection
How is Salmonella spread?
Entrance into the bloodstream after infection; transmitted by chronic carriers of S. Typhi
Signs and Symptoms
Asymptomatic is most common; fever, headache, prostration, splenomegaly, and leukopenia
enhanced virulence of strains that produce this antigen, associated with bacterial capsule
Causitive agents of Paratyphoid fever
Salmonella paratyphi A; Salmonella sedai
Salmonella paratyphi B; Salmonella choleraesuis
Diagnosis for virulent salmonella
Antibodies to Vi antigen of S. typhi used to screen for typhoid carriers
Immunologic Manifestation of Rickettsial Diseases
Antibodies appear in 7-10 days; specific cell-mediated immune response important in immunity to rickettsiae
Important to remember about titers for Rickettsial Disease
Lower titer= exposure to organism but no symptoms
Tests for Rickettsial Diseases
Weil-Felix reaction; Direct immunofluorescence used to confirm; complement fixation and latex agglutination available
What are Febrile agglutinin
antibodies produced in response to a variety of different pathogenic organisms
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