# Failures of the Immune System - 6/08

__________________ ____________________ is an epithelial defect where the thymus and a few other structures fail to develop. This means that an individual would be born with no T cells
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In a developing B cell, first the _____ and ______ segments combine which is a _____-____ _____________. Then, the _____ segment joins the D-J segment. This process was naturally made to be inaccurate because when two pieces of DNA are joined together, random bases can insert between them, forming ________________ of different sizes. If a junction is a multiple of _____ then it is a successful rearrangement which gives us a protein. If it is unsuccessful, then we cannot make a heavy chain protein. If it is successful, a ____-______ ____________________ is formed. This receptor is made to identify cells which have made good rearrangements and allow them to expand. This expansion requires signaling from ________________ __________________ __________________. This means that the pre-B receptor serves as a _____________________.
Normally, a stem cell develops into a _________________ ________________ __________________ which can further develop into B cells, T cells or Natural Killer cells. ________ will bind to the _______ ________________ on lymphoid progenitor cells to signal differentiation of T cells. In certain immunodeficient diseases, the genetic code of this receptor is defective which prevents IL-7 from binding to it and thus ruins the ability for progenitor cells to differentiate into T cells
The number of B lymphocytes and T lymphocytes in the blood is an important component of the clinical diagnosis of primary immunodeficiencies. Which disorder would be most likely to lead to low blood counts of T cells and B cells?