MIS Lecture 59.
Describe the clinical features of immunodeficiency disease.
Outline immunodeficiency disease classification: primary vs secondary immunodeficiency, T cell-mediated vs antibody-mediated immunodeficiency, and combined immunodeficiency.
Describe the link between immunodeficiency and ageing and the concept of immunosenescence.
Outline the process of transient hypogammaglobulinemia of infancy.
Outline the aetiology and clinical features of prototype antibody deficiency syndromes: X-linked agammaglobulinemia (XLA) and hyper-IgM syndrome.
Outline the aetiology and clinical features of prototype cell-mediated immunodeficiency syndromes: DiGeorge syndrome, Severe Combined Immunodeficiency Syndrome (SCID).
Outline the clinical features of terminal complement pathway deficiency.