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Unit 9 Quiz Prep
Terms in this set (88)
alter levels of the neurotransmitters norepinephrine, serotonin and dopamine in the brain.
antidepressants reduce symptoms that are associated with
depression, anxiety, post-traumatic stress disorder (PTSD) and obsessive-compulsive behavior.
antidepressants increase neurotransmitters when?
After the first dose
The clinical picture may not improve for how many weeks when using antidepressants?
2 - 4 weeks.
Categories of antidepressants
Tricyclic antidepressants (TCAs)
monoamine oxidase inhibitors (MAOIs)
selective serotonin reuptake inhibitors (SSRIs)
work by blocking the re-uptake of both norepinephrine and serotonin in the synapse of neurons
Black Box warning for tricyclic antidepressants
signs of suicide, especially at the beginning of treatment and when dosages are changed. Children and teens at greatest risk.
Anticholingeric side effects of tricyclic antidepressants
dry mouth, constipation, urinary retention, drying of the nasal passages, tachycardia and blurred vision.
Most common side effect of tricyclic antidepressants
Tricyclic withdrawl syndrome
occurs when pt. stops taking tricyclic abruptly. Pt. should be slowly weaned from the med.
Example of Tricyclic Antidepressants
amiltriptyline (Elavil), nortriptyline (Aventyl), imipramine (Tofranil), clomipramine (Anafrnil), doxepin (Sinequan), desipramine (Norpramin)
Monoamine Oxidase Inhibitors action
work by blocking or inhibiting MAO which causes breakdown of norepinephrine, dopamine, and serotonin
MAOIs are used only for who?
Patients who don't respond to other classes of antidepressants.
Side Effects of MAOIs
orthostatic hypotension, H/A, weight gain, insomnia, diarrhea, sexual dysfunction. potential hepatotoxicity.
MAOIs used with antihypertensives can cause
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