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5 Written questions

5 Matching questions

  1. Cryoglobulinemia‐
  2. Anaphylaxis‐
  3. Type 2 hypersensitivity reaction cytotoxic hypersensitivity
  4. Dosing for epinephrine
  5. Prostaglandins effects
  1. a 1 mg 1:1000
    0.01 mg/kg IM
    Max 0.5 mg in adult
    Max 0.3 mg in child
  2. b Cold agglutinins->activation of compliment & plts, hyper‐viscosity, renal failure
  3. c Bronchoconstriction
  4. d Life threatening manifestation of antigen‐antibody reaction
  5. e Antigens are normally endogenous, although exogenous chemicals (haptens) which can attach to cell membranes
    Drug-induced hemolytic anemia, granulocytopenia & thrombocytopenia
    IgM & IgG mediated
    Phagocytes & K cells play a role

5 Multiple choice questions

  1. Not IgE mediated, similar clinical presentation, don't need prior sensitization
  2. Airway emergency
    C1 esterase inhibitor->poorly regulated compliment activation->release of vasoactive mediators (bradykinin)->episodic airway edema
  3. Emotional stress triggers 30-40% of attacks
  4. 1 mg IV
  5. Antihistamines & epinephrine doesn't work
    C1 esterase inhibitor

5 True/False questions

  1. Multiple myelomaAntigen-antibody, hypotension, bronchospasm, urticaria, unpredictable severity, prior exposure, rapid onset, not dose related, low incidence


  2. Allergic reactionsNot IgE mediated, similar clinical presentation, don't need prior sensitization


  3. Effects of anaphylaxisO2, IV fluids, epinephrine, H1 antagonists, steroids


  4. Cold hemagglutinin disease‐IgM binds erythrocytes when cold->hemolysis, compliment activation, acrocyanosis, Raynaud's, purpura, gangrene, nephritis


  5. Drug allergyRare, accounts for 1% of adverse reactions to locals
    Ester based->PABA
    Preservatives (methylparaben, propylparaben) similar to PABA
    No proven cross-reactivity between ester & amides