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5 Written questions

5 Matching questions

  1. What triggers angioedema
  2. S/S of anaphylactoid reactions
  3. Disorders of immunoglobulins
  4. Drug allergy: Muscle relaxants
  5. Drug allergy: protamine
  1. a Degranulations & release of vasoactive mediators->hypotension & CV collapse
  2. b Account for 60% of periop drug induced allergic reactions
    High incidence (50%) of cross sensitivity
    Quaternary ammonium groups (nondepolarizers)
  3. c Emotional stress triggers 30-40% of attacks
  4. d Deficiencies:
    X-linked agammaglobulinemia
    Acquired hypoimmunoglobulinemia
    Selective immunoglobulin A deficiency
    Cold autoimmune diseases
    Multiple myeloma
    Waldenstrom's macroglobulinemia
  5. e Derived from salmon semen
    ↑d incidence in pts allergic to seafood, diabetics, vasectomized males)
    Protamine induced compliment activation->thromboxane->bronchoconstriction & pulm HTN (↑d PAP)
    Peripheral vasodilation

5 Multiple choice questions

  1. Itching, conjunctivits, rhinitis, laryneal & angioedema, urticaria, bronchospasm (asthma), dysrhythmias, hypotension, GI cramps & malabsorption
  2. Sensitization via antigen specific IgE antibodies
  3. Capillary permeability
  4. Mast cells, Anaphylaxis and allergy
  5. Life threatening manifestation of antigen‐antibody reaction

5 True/False questions

  1. Drug allergy: abxHalothane hepatitis- trifluoroacetyl halide metabolites + hepatic microsomal proteins->neoantigens
    Sevo doesn't produce oxidative halide metabolites


  2. IgGImmunity, defense against infection


  3. Allergic reactionsAnaphylaxis‐ IgE mediated reaction
    Rhinitis‐ IgE mediated
    Food & drug allergies


  4. Drug allergy: latex↑d incidence in medical personnel (15% in
    Patients w/ multiple surgeries, fruit (banana)
    allergies & spina bifida
    Potential for delayed reaction (>30 minutes)


  5. Dosing for epinephrineManifestations dependent upon drug
    Fairly predictable
    No prior exposure needed
    Dose related
    Onset may be delayed