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5 Written questions

5 Matching questions

  1. Treatment for hereditary angioedema
  2. Drug allergy: crossmatched blood
  3. Cryoglobulinemia‐
  4. Vasoactive mediators
  5. S/S of anaphylactoid reactions
  1. a Histamine, leukotrienes, prostaglandins, eosinophil & neutrophil chemotactic factor, plt activating factor
  2. b Cold agglutinins->activation of compliment & plts, hyper‐viscosity, renal failure
  3. c 3% incidence of allergic reactionst
  4. d Antihistamines & epinephrine doesn't work
    C1 esterase inhibitor
  5. e Degranulations & release of vasoactive mediators->hypotension & CV collapse

5 Multiple choice questions

  1. Deficiencies:
    X-linked agammaglobulinemia
    Acquired hypoimmunoglobulinemia
    Selective immunoglobulin A deficiency
    Cold autoimmune diseases
    Multiple myeloma
    Waldenstrom's macroglobulinemia
  2. Neoplastic proliferation of IgM secreting plasma cell->hyper‐ viscosity, infiltration of liver, spleen, lungs, & bone marrow
  3. Sensitization via antigen specific IgE antibodies
  4. Hereditary angioedema
  5. Secretions, topical defense

5 True/False questions

  1. Dosing for epinephrine for shock but w/ pressure1 mg 1:1000
    0.01 mg/kg IM
    Max 0.5 mg in adult
    Max 0.3 mg in child


  2. Drug allergy: LAsRare, accounts for 1% of adverse reactions to locals
    Ester based->PABA
    Preservatives (methylparaben, propylparaben) similar to PABA
    No proven cross-reactivity between ester & amides


  3. Anaphylactoid reactionsDegranulations & release of vasoactive mediators->hypotension & CV collapse


  4. Anaphylaxis secondary exposureMassive degranulation of mast cells & basophils


  5. Drug allergy: protamineDerived from salmon semen
    ↑d incidence in pts allergic to seafood, diabetics, vasectomized males)
    Protamine induced compliment activation->thromboxane->bronchoconstriction & pulm HTN (↑d PAP)
    Peripheral vasodilation


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