7586 Week 2/3 Mechanism of Action of Drugs (Dunn)

non-opioids
Click the card to flip 👆
1 / 4
Terms in this set (4)
- ASA (Bayer, Bufferin, Ecotrin): irreversible inhibitor of COX-1 and COX-2 enzymes resulting in decreased formation of prostaglandins
- APAP (Tylenol, Ofirmev): inhibits prostaglandin synthesis in the CNS and peripherally blocks pain impulse generation; provides antipyretic activity via inhibition of hypothalamic heat-regulating center
- NSAIDS: inhibition of COX-1 and COX-2 enzymes leading to prevention of prostaglandin formation; provides short-term, reversible platelet inhibition
- celecoxib (Celebrex): selective COX-2 inhibitor leading to prevention of prostaglandin formation
- tramadol (Ultram, Ultram ER, Ryzolt, ConZip); tramadol + APAP (Ultracet): binds to mu opioid receptors to inhibit ascending pain pathways; also inhibits NE and serotonin reuptake
- tapentadol (Nucynta): binds to mu opioid receptors to ascending pain pathways; also inhibits NE reuptake
- Weak, Moderate, and Strong Agonists: bind to opioid receptors mu, kappa, and delta to prevent pain
- Mixed Agonists-Antagonists: exert their analgesic activity via the kappa opioid receptor and either block or act as partial agonists at the mu opioid receptor