13 terms

Set 8 - AA Catabolism C-Skeleton

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Glucogenic amino acids
when catabolized, certain C-skeletons form pyruvate or TCA cycle intermediates and have the potential to produce glucose (via gluconeogenesis)
Ketogenic amino acids
when catabolized, certain C-skeletons form acetoacetyl CoA or acetyl CoA and have the potential to produce ketone bodies
Exclusively ketogenic amino acids
Leucine & lysine
Exclusively glucogenic amino acids
Alanine, Asparagine, Aspartate, Glutamine, Glutamate, Isoleucine, Phenylalanine, Tryptophan, Tyrosine
phenylalanine hydroxylase
phenylalanine --> tyrosine
phenylpyruvate
produced during high levels of phenylalanine; detected in urine using FeCl3 to test for PKU
Tyrosine catabolism
forms homogentisate following aminotransferase reaction;
homogentisate further broken down into fumarate acetoacetate (eventually acetoacetyl CoA)
alkaptonuria
elevated levels of homogentisate due to lacking homogentisate 1,2-dioxygenase
Final C-Skeleton of Tryptophan
Pyruvate, Acetoacetyl CoA
Final C-Skeleton of Leucine
Acetyl CoA, Acetoacetyl CoA
Final C-Skeleton of Lysine
Acetoacetyl CoA
Final C-Skeleton of Isoleucine
Propionyl CoA, Acetyl CoA
Final C-Skeleton of Phe & Tyr
Fumarate, Acetoacetyl CoA