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Steady State
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Terms in this set (5)
When is steady state achieved
The rate of drug input = the rate of drug output
Clinically we assume the patient is at steady state after 95% of true steady state is achieved. Therefor how many half-lives
5 half-lives
Methods to alter steady state: The plasma concentrations achieved at steady state depend on the drug's
1. CL
2. Vd
3. Dose
4. Dosing interval (Tau)
What can be changed to alter steady state (CL, Vd, Dose, Dosing Interval)
Dose and Dosing interval (Tau)
CANNOT change volume and clearance
Reasons to alter Css
1. Steady state concentrations are relatively low (not reaching predicted concentrations)
or
2. If the steady state levels are high and the patient is experiencing toxic effects (keep in therapeutic range)
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