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Pharm GI medications
Terms in this set (44)
Work by enhancing mucosal protrction mechanisms
Binds to injured tissue, forms barrier. Speeds up healing of peptic ulcers and decreases returning ulcers
Stimulate prostaglandin release, mucus, and bicarb output
Drawback of taking sucralfate?
4x a day
Can interfere with absorption of other drugs
Take 1 hour before meal
Bismuth sub-citrate K+
Treat H pylori
Bismuth subsalicylate (Pepto-Bismol)
Costs ulcers and makes protective layer against acid and pepsin
Decreased stool freq and liquidity
Causes BLACK stools
Inhibit >90% basal, food stimulated, and nocturnal secretion of gastric acid after one dose
Can slow or potentials action of other drugs
Don't take if taking meds that need acid to absorb (ketoconazole and iron)
H2 blockers end in ?
PPI end in?
PPI suppress secretion of ____ into gastric lumen. Gastric acid suppression is _____ hours after 1st dose.
What can be taken to decrease bleeding risk from ASA or other NSAID related ulcers?
Long term concerns for taking PPI?
Possibly increase acute interstitial nephritis and CKD risk
Use ____ as a source of Ca if prolonged use of acid- suppressing meds
PPI may decrease metabolism of ___.
What's inhibits metabolism of warfarin, phenytoin, and cyclosporine?
When to take PPI and H2 blocker?
PPI 30 min before breakfast
H2 blocker at night
How to treat GERD with mild s/s?
Antacids or H2 blockers if s/s >2 hours
How to treat moderate s/s of GERD?
When s/s happen several times/wk or daily. PPI daily/ prescription strength H2 blocker BID tx for 4-8 weeks
How to treat severe s/s of GERD erosive disease?
PPI daily increase to BID X 8-12weeks
Goals of treatment of PUD?
Get rid of H pylori infection
Decrease gastric acid secretion (H2 blockers, PPI)
Give drugs that protect gastric mucosa from damage (bismuth and sucralfate)
The optimal tx for PUD with H pylori infection?
No mono therapy
Bismuth quadruple therapy
When should antidiarrheal agents not be used?
Or systemic toxicity
Kakpectate- Kaolin+ Pectin
Antidiarrheal that absorbs toxins and fluid in infectious diarrhea
Decreased bioavailability of co-administered drugs
What antidiarrheals have opioid like actions on the guy and decrease peristalsis?
Potential for abuse wirh ____ d/t atropine
An antidiarrheal that can be abused causing euphoria
The expensive antidiarrheal that you can't use with hx of pancreatitis , ETOH, or known sphincter of Oddi disease?
Best tx for chronic diarrhea?
Best tx for acute diarrhea?
Opiates and opioid derivates
1st line treatment for c diff?
Vanc (fidaxomicin) add probiotics
Laxatives that increase bulk and moisture content of stool
Can stimulate colonic bacterial stool leading to bloating and flatus
Laxatives that cause water to move from tissues into bowel to increase bulk and increase peristalsis.
Types of osmotic/ hyperosmolar laxatives?
Polyethylene glycol (miralax)
Used to chronic constipation and tx of hepatic encephalopathy
This osmotic laxative is not absorbed systemically so decrease incidence of ADE than other osmotics
Can be used at low dose daily for 6 months
Also used in large dose for bowel prep
Type of osmotic saline laxative?
Magnesium (milk of mag)
Not for routine use
Senna, cascara, dulcolax (bisacodyl) are what types of laxatives?
What are the expensive laxatives? Newer
What is the BBW for Linaclotide (linzess)?
Avoid in <18 and CI in peds
Preferred laxatives for pregnant women?
Bulk laxatives/ stool softeners
Lactulose, psyllium, miralax, methylcellulose, colace, senna
General tx algorithm for constipation?
No drugs first
Then add stimulant
What antiemetics may cause prolonged QT interval?
Dementia related psychosis, increase mortality in elderly dementia patients
Can exacerbate preexisting psych conditions
For this disease, immunosuppression is often used and drugs are chosen based off disease severity, responsiveness, and drug toxicity
Dicyclomine Hydrochloride (Bentyl)
Used for IBS and other GU probs
Relaxes smooth muscle and inhibits spasms
What drugs can Bentyl increase effects of?
Dig and atenolol
Dissolve non calcified gallstones that are radiolucent
Used for 3 months
Pain fever jaundice
Can give to preg/peds
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