vitamin Aprecursor to rhodopsin, carrots number one source of vitamin A
tuna secondeicosanoidschemical messengers
inflammation, intraoccqular pressuresimple lipids = esters of fatty acidstriglyceridescomplex lipids (esters of fatty acids + additional groups)phospholipid
sphingolipidsderived lipids (derived from hydrolysis of simple/complex lipids)steroids (ex: bile salts, steroid hormones, sterols)
isoprenoids (ex: vitamins A, E, K)
eicosanoids (ex: prostaglandins, leukotrienes, thromboxanes)fatty acid what is ithydrocarbon chain with carboxyl group at one end
even number carbons (10-30)most common saturated fat in plants and animalspalmitic acid (hexadecanoic acid)position of first double bond relative to methyl endomega carbon
(farthest from carboxyl group)simple lipid that are important to eyeeicosapentaenoic acid (EPA) - fatty fish
docosahexaenoic acid (DHA) - fatty fish
alpha linolenic acid (ALA) - flaxseed, walnuts
arachidonic acid - meat and egg yolk
linoleic acid - plant oils, nutssingle bonds in hydrocabron chainsaturated
linear
soliddouble bonds in hydrocabon chainunsaturated
bent
liquid
cis or transcis2 hydrogens attached same side
most naturally occuring unsaturated fatty acids are cistranstwo hydrogens, opposite side of double bond
most are industrial process adds hydrogens to liquid vegetable oils to make more solid
hydrocarbon chain is straight (EVEN THOUGH UNSATURATED)trans unsaturated fatty acidsSTRAIGHT HYDROCARBON TAILSester of a fatty acidalcohol + fatty acid
alcohol = glycerol or sphingosinetriglycerides made of3 fatty acids + glycerol
(length + degree of saturation varies)
storage form of fatty acidsphospholipids made of2 fatty acids + glycerol + phosphate + 1 polar grouppossible polar groups of phospholipidsethanolamine - cell membranes + pharmaceuticals
choline - maintenance of cell membranes
serine - metabolism and maintenance of immune system
inositol - fruid, seeds, gains - important for signal transductionsphingolipids structurefatty acids + sphingosine + 1 head grouppossible head groups of sphingolipids structurehydrogen (ceramide - major component of lipid bilayer + component of aqueous humor)
phosphocholine (sphingomyelin) - retinal diseases (macular degeneration, diabetic retinothapy, glaucoma)
sugar (glycolipid: 1 sugar = cerebroside, > 1 sugar = ganglioside)1 sugarcerebrosidemore than one sugargangliosidesteroid (derived lipid) structuresteroid core + side chain
core = four fused rings
side chains: uniquesterol
structurestructure: side chain is a hydroxyl groupmost common sterolcholesterolcholesterol is the most common steroid and it is the precursor to _____________ and _____________steroid hormones and bile saltstwo important bile acids in humanscholyl-CoA
chenodeoxycholyl-CoAreaction of bile acids to bile saltsacid conjugated with glycine or taurine reaction produces water and chemical saltsbile salts
where stored
what does it aid inderivative of cholesterol
stored in: gallbladder
what does it aid in: dietary lipids (emulsification) + absorption of fat-soluble vitamins A, D, E, Kfour types of steroid hormonesmineralocorticoids
glucocorticoids
sex steroids
vitamin Dmineralocorticoids
examples
what do they doexamples: corticosterone, aldosterone
what do they do: regulate H2O and salt balanceglucocorticoids
examples
what do they doexamples: cortisol
what do they do: regulate stress management, inflammation, suppress immune systemsex steroids
examples
what do they doexamples: regulate sexual development + function
what do they do: progesterone, testosterone, estrogenvitamins D
examples
what do they doexamples: some true steroid characteristics
what do they do: regulate calcium memtabolismnatural steroid hormones derived from cholesterol and all have four ring structure
can these pass through cell membrane?yes, they can pass through cell membrane and bind to steroid receptorsisoprenoids
structure
examplestructure: isoprene subunits (unsaturated, pentahydrocarbon)
examples: fat-soluble vitamins A, E, Keicosanoids
derived from
examplesderived from: arachidonic acid (Poly unsaturated omega-6 FA)
examples: prostaglandins, leukotrienes, thromboxanes
signalling moleculesarachidonic acidan omega-6 fatty acidprostaglandins roleinflammation, pain, edema
decrease platelet adhesion'
elevated in tears for dry eyethromboxane roleplatelet aggregationleukotrienepotent bronchoconstrictors
bronchial asthma, ARDSprostacyclininhibits platelet aggregationprostaglandin analogsfirst choice to treat glaucoma
mimics function of naturally occurring prostaglandin
prostaglandin E2
thromboxane A2 (TXA2)
prostacyclin (PGI2)
leukotriene B4