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schizophrenia - study
Terms in this set (11)
A decrease in speech or speech content; a symptom of schizophrenia. Also known as poverty of speech.
- dysfunction of communication; restrictions in fluency and productivity of thought and speech affective blunting or flattening. Restrictions on range of intensity of emotional expression.
The Five A's of Negative Symptoms
Negative symptoms are largely biggest determinant on whether a patient will be able to prosper
Reduced social drive an interaction
Reduced ability to experience pleasure
Reduced desire, motivation or persistence; restrictions in the initiation of goal-directed behavior
Positive symptoms are a result of...
Too much dopamine in the mesolimbic region of the brain
Tx: dopamin (D2) blockers
Negative symptoms are a result of...
A lack of dopamine in the mesocortical prefrontal regions
3 Treatment phases
1. Acute Episode: first 7 days: decreased agitation, hostility, anxiety, tension, aggression
2. Stabilization Therapy:
- Response determine at 2-4 weeks. If no response -> change therapy.
- May take psychosis 6-8 weeks to respond
- Up to 12 weeks
3. Stable / Maintenance Phase: Prevent relapse, treatment for at least 1 year. Up to 5 years and possibly lifetime. Taper off therapy
Progression of Extrapyramidal Symptoms
Acute Dystonia -> Akathisia -> Tardive Dyskinesia
The drug considered one of the most effective antipsychotic
--> can cause agranulocytosis
CBC weekly for 6 months
every 2 weeks for 6-12 months
monthly after 12 months
** Reserved for treatment resistant, failed at least 2 trials
How to monitor anti-psych medications for PCP
Fasting Blood Glucose and Fasting Lipid Panel: Baseline, 12 months, annually
BP and weight / BMI: baseline and every visit
Waist circumference: baseline, annually
ECG: baseline & periodically during therapy
AIM (abnormal involuntary movement) scale every 3-6 months (assess for movement disorders)
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