Like this study set? Create a free account to save it.

Sign up for an account

Already have a Quizlet account? .

Create an account

Name the Potassium Sparing Diuretics.


What is the mechanism of action for potassium sparing diuretics?

Sythetic Aldosterone Antagonists - competes with aldosterone at renal receptor sites (Aldosterone normally stimulates Na+ reabsorption & K+ elimination at the distal tubule)
Causes Na+ elimination & K+ reabsorption

What are the therapeutic uses for Potassium sparing diuretics?

Improve morbidity & mortality in left ventricular systolic dysfunction (CHF with ejection fraction <40%); slows CHF disease profession.
Used in combination with thiazides or loops to help retain K+ & prevent hypokalemia.
Reduce portal vein HTN in liver failure pts with ascites.

How powerful are potassium sparing diuretics?

Not powerful enough as a diuretic to be used alone to treat edema.
Can be added when pt has resistant HTN (where pts are already on 3 or more drugs)

What is eplerenone generally reserved for & why?

Eplerenone is generally reserved for pts experiencing sex hormone-related side effects of spironolactone due to its increased cost ($115/mo as compared to $20/mo)

What are the adverse effects of potassium sparing diuretics?

Hyperkalemia (Can be life-threatening)
Spironolactone, since it chemically resembles some sex steroids, may cause gynecomastia (10%) in men & menstrual irregularities & deepening of voice in females. Eplerenone is more selective & does not cause these side effects.

What are the contraindications/precautions of using potassium sparing diuretics?

Serum K+ >5.5 mEq/L at initiation or CrCl <30 mL/min.
Use extreme caution if pts are receiving K+ supplements, ACE-I, ARBs, or using salt substitutes.
Eplerenone use is contraindicated with powerful CYP3A4 inhibitors such as macrolides, ketaconazole, itraconazole & others.

Name the K+ supplements.


What is the mechanism of action for amiloride & triamterene?

NOT aldosterone antagonists.
Act directly in the distal renal tubule to inhibit the Na+ reabsorption & K+ elimination that is normally stimulated by aldosterone.

What are the therapeutic uses for amiloride & triamterene?

Mostly used to help retain K+ & prevent hypokalemia; NOT used in management of CHF or portal vein HTN like spironolactone

What are the adverse effects of amiloride & triamterene?

RIsk of hyperkalemia is just as much of a concern; do NOT cause hormone-related ADRs

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions and try again


Reload the page to try again!


Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

Voice Recording