a. Injury produces a defect in skin --> incites an inflammatory reaction.
b. Blood clot (fibrin and fibronectin).
c. Epithelium regenerates and migrates to cover the defect.
d. Cells (fibroblasts, myofibroblasts, macrophages) proliferate and migrate into the deflect (filled with clot).
--Macrophages remove debris, such as dead cells, and secrete cytokines.
--Fibroblasts, under chemical mediation, produce extracellular connective tissue matrix.
--Myofibroblasts contact the wound.
e. Simultaneously, capillaries (endothelium) at the edge of the defect proliferate and extend into the defect under the influence of chemical mediation.
f. Over time (weeks to months) the defect filled with granulation tissue becomes remodeled into mature collagen (scar) and parenchymal cells. The wound acquires strength through this process (vitamin C required).