11 terms

Toll-like receptor (TLR)

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TLR 1 and 2
binds to bacterial lipopeptides and GPI-anchored proteins in parasites
TLR 2 and 6
binds to lipoteichoic acid of gram+ bacteria and zymosan produced by fungi
TLR 4
binds to LPS from gram- bacteria
TLR 5
binds to flagellin
TLR 3
binds to double-stranded viral RNA
Ex. West Nile virus
TLR 7
binds to single-stranded viral RNA
Ex. HIV
TLR 8
binds to single-stranded viral DNA
TLR 9
binds to CpG DNA from bacteria/viruses
Pathogen-associated molecular patterns
PAMPs
Pathogen recognition receptor
PRR
recognizes PAMPs
common PAMPs
flagellin, LPS (Gram-), peptidoglycan (Gram +/-), lipoteichoic acid (Gram+)
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