5 Written questions
5 Matching questions
- SNAPs (soluble NSF-attachments proteins)
- Electrical synapses
- NSF (NEM-sensitive fusion protein)
- a chemical agents acting as messengers between the communicating neurons. Released from vesicle when the is a large Ca++ influx into the cell. How many are released depends on how much Ca++ enters the terminal.
- b an ATPase involved in priming synaptic vesicle for fusion
- c Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.
- d with the aid of auxilin, this removes the clathrin coating so that the vesicle can move onto other phases of recycling
- e Involved in priming synaptic vesicles for release. Work by regulating the assembly of SNARE proteins.
5 Multiple choice questions
- neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
- Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.
- partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
- a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
- a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
5 True/False questions
synapsin → reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
small clear-core vesicle → Package neuropeptides. These vesicles are much larger in size than small clear-core vesicles. Made in the soma and shipped down to the terminal via fast axonal transport.
dynamin → reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
acetylcholine (ACh) → a very important protein involved in endocyctotic budding of vesicles from the plasma membrane. Assemble together (by polymerization) to form membrane coats during the budding of the phase synaptic vesicle cycle.
end plate potential (EPP) → membrane potential on an end plate large enough to trigger an action potential