5 Written questions
5 Matching questions
- large dense-core vesicles
- acetylcholine (ACh)
- Electrical synapses
- end plates
- a with the aid of auxilin, this removes the clathrin coating so that the vesicle can move onto other phases of recycling
- b Package neuropeptides. These vesicles are much larger in size than small clear-core vesicles. Made in the soma and shipped down to the terminal via fast axonal transport.
- c A neurotransmitter found primarily at neuromuscular junctions of the striated muscles and in the visceral motor system. Involved in muscle contraction and heart rate increases.
- d neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
- e Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.
5 Multiple choice questions
- Involved in priming synaptic vesicles for release. Work by regulating the assembly of SNARE proteins.
- a V-SNARE protein that binds to the synaptic vesicle before exocytosis
- Vesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.
- a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
- partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
5 True/False questions
synapsin → a protein that causes the final pinching-off of the membrane that completes the production of coated vesicles in the synaptic vesicle cycle.
dynamin → reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
Gap Junctions → Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.
synaptic vesicle cycle → recycling process for synaptic vesicle. Process takes about 1 minute.
syntaxin and SNAP-25 → T-SNARE proteins embedded to the pre-synapatic membrane; attach to synaptic vesicles for vesicle fusion