5 Written questions
5 Matching questions
- synaptic vesicle cycle
- SNAPs (soluble NSF-attachments proteins)
- small clear-core vesicle
- a a protein that causes the final pinching-off of the membrane that completes the production of coated vesicles in the synaptic vesicle cycle.
- b Vesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.
- c with the aid of auxilin, this removes the clathrin coating so that the vesicle can move onto other phases of recycling
- d Involved in priming synaptic vesicles for release. Work by regulating the assembly of SNARE proteins.
- e recycling process for synaptic vesicle. Process takes about 1 minute.
5 Multiple choice questions
- membrane potential on an end plate large enough to trigger an action potential
- T-SNARE proteins embedded to the pre-synapatic membrane; attach to synaptic vesicles for vesicle fusion
- A neurotransmitter found primarily at neuromuscular junctions of the striated muscles and in the visceral motor system. Involved in muscle contraction and heart rate increases.
- How neurotransmitters are referred to when two or more of them are present in the same nerve terminal.
- reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
5 True/False questions
synaptotagmin → a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
curare → a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
clathrin → a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
CamKII → a very important protein involved in endocyctotic budding of vesicles from the plasma membrane. Assemble together (by polymerization) to form membrane coats during the budding of the phase synaptic vesicle cycle.
Gap Junctions → a protein that causes the final pinching-off of the membrane that completes the production of coated vesicles in the synaptic vesicle cycle.