5 Written questions
5 Matching questions
- end plates
- mini end plate potentials (MEPPS)
- acetylcholine (ACh)
- Electrical synapses
- a make up EPPS and correspond to the release of just one or two vesicle. Small, happen spontaneously, and cannot trigger an AP.
- b Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.
- c A neurotransmitter found primarily at neuromuscular junctions of the striated muscles and in the visceral motor system. Involved in muscle contraction and heart rate increases.
- d a V-SNARE protein that binds to the synaptic vesicle before exocytosis
- e neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
5 Multiple choice questions
- partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
- membrane potential on an end plate large enough to trigger an action potential
- a protein that causes the final pinching-off of the membrane that completes the production of coated vesicles in the synaptic vesicle cycle.
- a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
- T-SNARE proteins embedded to the pre-synapatic membrane; attach to synaptic vesicles for vesicle fusion
5 True/False questions
large dense-core vesicles → Vesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.
CamKII → a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
small clear-core vesicle → Package neuropeptides. These vesicles are much larger in size than small clear-core vesicles. Made in the soma and shipped down to the terminal via fast axonal transport.
Neurotransmitters → chemical agents acting as messengers between the communicating neurons. Released from vesicle when the is a large Ca++ influx into the cell. How many are released depends on how much Ca++ enters the terminal.
Gap Junctions → Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.