5 Written questions
5 Matching questions
- Electrical synapses
- end plates
- large dense-core vesicles
- a partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
- b Package neuropeptides. These vesicles are much larger in size than small clear-core vesicles. Made in the soma and shipped down to the terminal via fast axonal transport.
- c a V-SNARE protein that binds to the synaptic vesicle before exocytosis
- d Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.
- e neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
5 Multiple choice questions
- recycling process for synaptic vesicle. Process takes about 1 minute.
- membrane potential on an end plate large enough to trigger an action potential
- Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.
- reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
- a very important protein involved in endocyctotic budding of vesicles from the plasma membrane. Assemble together (by polymerization) to form membrane coats during the budding of the phase synaptic vesicle cycle.
5 True/False questions
small clear-core vesicle → Vesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.
mini end plate potentials (MEPPS) → make up EPPS and correspond to the release of just one or two vesicle. Small, happen spontaneously, and cannot trigger an AP.
co-transmitters → How neurotransmitters are referred to when two or more of them are present in the same nerve terminal.
syntaxin and SNAP-25 → T-SNARE proteins embedded to the pre-synapatic membrane; attach to synaptic vesicles for vesicle fusion
NSF (NEM-sensitive fusion protein) → an ATPase involved in priming synaptic vesicle for fusion