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Terms in this set (13)

- Differin, Plixda

- Drug class: Retinoid, Antiacne

- Indications: Acne vulgaris

-MOA: Adapalene exhibits retinoic acid-like activity, reducing important features of the pathology of acne vulgaris by normalizing the differentiation of follicular epithelial cells and keratinization to prevent microcomedone formation. Adapalene enhances keratinocyte differentiation without inducing epidermal hyperplasia and severe irritation, which is associated with retinoic acid. Adapalene decreases formation of comedones, and inflammatory and noninflammatory acne lesions

- Drug interactions: photosensitizing agents

- common adverse reactions: Dry skin, scaly skin, erythema, burning/stinging

Rare but serious ADR: angioedema

Efficacy monitoring: improvement in acne

Toxicity monitoring: severe dry skin or sever skin irritation

Patient counseling points: Avoid contact with eyes, lips, angles of nose and mucous membranes. Do not apply on cuts, abrasions, eczematous or sunburned skin. wash hands and affected area prior to application. Use of moisturizers may be necessary for relief of dry skin or irritation. Avoid products that can dry or irritate skin further. If cutaneous reactions occur and are sever, the frequency should be reduced or adapalene discontinued. Other topical preparations should not be used prior to using topical adapalene. Adapalene causes sun-sensitivity. Avoid sun exposure and tanning beds. Protective clothing and application of sunscreen are recommended when sun exposure cannot be avoided. Cold temperature or wind may also increase skin irritation during drug therapy. Symptomatic improvement may not be seen for up to 12 weeks