thromboxanessimilar effects to histamine; platelet activationGraunlocytesBEN; grains of histamine- prolong and increase inflammationBasophilsgranulocyte, not sure what they doeosinophilsgranulocyte and diapedidic; only WBC that fights parasites. travels and regulates histamine releaseneutrophilsPhagocyte, diapededic, and granulocyte. releases histamine, eats stuff then explodes (pus) and travelsDendriticphagocyte; Venus fly trap sticks to BV wall and grabs stuff that floats by, rips their faces off to present to T and B cells as an antigen presenting cell (APC)
in peripheral organs and skin
migrate through lymph vesselsmacrophage / monocytephagocyte, diapededic. use lysosomes to dissolve the pathogens, spits out unprocessed stuff and wears it to present to T and B cells as APC. Arrives to site 24 hours or later
national guardPhagocyteseats stuffDiapededic cellstravel and squeeze in and out of the blood vesselsphagocytosisprocess by which a cell ingests and disposes of foreign materialpavementingDendritic cells, adherence of leukocytes to endothelial cellsplamsa protein systemsprotein systems circulate in blood and assist in the immune responsecomplement systemPPS; tagging system. tag/stick to foreign things in blood.
can destroy directly.
can collaborate with every other component of the inflammatory response (attractive to phagocytes)coagulation (clotting) systemPPS. stops bleeding by forming a fibrinous meshwork at an injured or inflamed siteKinin systemPPS. activated and assists inflammatory cells
primary is Brady kinin which causes paincytokinescellular products released for communication and controlinterferonsignal that protects against viral infections. paracrine signal: warns its direct neighborpurpose of inflammationrecruitment of immune cells, limits infection from causing further damage and stabilizes tissues to initiate and facilitate healinglocal manifestations of inflammationSHARP
Swelling
Heat
A possible loss of function
Redness
Painacute inflammationself limiting, should not spread to other areasChronic inflammationlasting two weeks or longer; often related to an unsuccessful acute inflammatory responseExudative fluidsfluids coming from a woundserous exudateindicate early inflammation (mostly blood plasma)Fibrinous Excudatescar tissue, indicates more advanced inflammationpurulent exudatepus- indicated a bacterial infection PHYSIO (from dead neutrophils)Hemorrhagic exudatebleedingwhat is the #1 hallmark of infectious disease?feverLeukocyotosisincreased # of WBC
