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Glycolysis by any other name...
Humans: lactic acid fermentation (pyruvate + H); Yeasts: alcohol fermentation
ATP production in Glycolysis
4, but 2 are used to phosphorylate glucose (to keep it inside the cell)
Lactic Acid Pathway
If anaerobic, extra Hs are given pyruvate to make lactic acid (only 2 ATPs per glucose; RBCs)
removes glucose from glycogen as glucose 6-phosphate (sk. muscles use directly, liver injects into bloodstream by removing phosphate)
1. lactic acid from sk. muscle goes to liver; 2. becomes pyruvate again; 3. glucose is added to liver's glycogen (gluconeogenesis)
formation of glucose by non-carbohydrates (amino acids, glycerol, pyruvate); non-carb > ketones > pyruvates > glucose
CO2 is clipped off of pyruvate (becomes acetyl CoA which carries acetic acid; comes from vit B5); CO2 goes to lungs
1. acetyl CoA combines w/ oxaloacetic acid (forms citric acid); 2. cycle occurs, citric becomes oxalo again; 3. Produces 1 GTP (guanasine triphosphate) which gives P to ADP; 4. 1ATP, 3NADH, 1FADH2
Electron Transport Chain
AKA Oxidative Phosphorylation 1. series of proteins in cristae of mitochondria (FMN, CoQ, Cytochromes); 2. energy used to phosphorylate ADP to ATP; 3. 26 ATPs formed
energy from ETC used to pump H's into outer mitochondrial chamber forming energy for forming ATP; H2O is formed at end with H's used
2. Acetyl CoA from Fat (Beta-oxidation)
clips acetyl CoA from fatty acid chains (10ATP/acetyl CoA, Beta-ox makes 4 itself)
found in children; used to produce lots of heat (instead of ATP; caused by uncoupling protein with H+ leakage by inner mito. membr.)
Triglycerides > Ketones > Acetone > Pungent fruit breath of much nasty (fasting causes fat to break down forming ketone bodies)
Amino Acid Metabolism...
1. Nitrogen is ingested from proteins; 2. body uses amino acids; 3. excreted as urea (NH3); 4. excess amino acids can be made into carbs & fat
creation of new amino acids catalyzed by transaminase by adding NH2 to pyruvate or ketones of Kreb's
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