Create an account
What are the components of blood?
45% cells (99% RBC), 55% plasma. Plasma proteins (albumin, globulin, fibrinogen, etc) are 98% of solutes in plasma
Plasma vs Serum
Plasma is blood minus cells (RBC, WBC, Platelets). Serum is plasma minus clotting elements (fibrinogen)
What kinds of proteins are in the plasma? (2)
1. Those at high concentrations (albumin, carrier proteins, immune proteins, proteins of blood coagulation) ALL PLASMA PROTEINS EXCEPT FOR THE IGS ARE MADE IN THE LIVER 2. Those at low levels with no functional role in the plasma
Main peaks in plama protein electrophoresis
Albumin and 4 globulins (A1 A2 Beta and Gamma). Variations in these peaks are indicative of certain diseases. Albumin peak is the only one that is albumin only, the rest are mixtures.
2 roles of albumin
Makes up 60% of plasma protein. 1. Maintains osmotic gradient 2. Transports hydrophobic molecules
Alpha1-Antitrypsin (2) (alpha1 globulin)
1. Inactivates trypsin and other proteolytic enzymes 2. Reduces damage from inflammation (its absense will lead to liver or lung disease)
Haptoglobin (alpha2 globulin)
Hemoglobin-binding protein, inhibits microbe iron uptake (binds to lysed hemoglobin and initiates breakdown)
Complement component 3 (beta globulin)
Helps regulate the inflammatory response to foreign substances
Late response (chronic inflammation)
v albumin, ^ A2, ^ gamma (same as immediate + gamma. Gamma up bc associated with infection)
v albumin, ^ gamma (bc albumin is made in the liver, a decrease in albumin causes an increase in gamma globulins to keep osmotic pressure up)
v albumin, ^ A2, v gamma (shows a reduction in low molecular weight proteins that leave the blood through the kidney, the liver INCREASES A2 globulins in response to lowered levels of albumin and gamma)
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together