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BIO 320 Lecture 14

Terms in this set (23)

Besides G protein-coupled receptors, the four major receptor classes and signaling pathways are:
1) TGF beta receptors
2) cytokine receptors
3) receptor tyrosine kinases
4) MAP kinase pathways
The TGF in TGF beta receptors stand for __ __ __
transforming growth factor
TGF beta work through the __ pathways
SMAD
Cytokine receptors work through the __ pathway
JAK STATs
Receptor tyrosine kinases work through the various pathways and are stimulated by __ __
growth factors
G protein-coupled receptors work through the __ pathway
CREB
TBFbeta is negatively regulated by __
ski
__ receptors activate the JAK-STAT pathway
cytokine
__ regulate growth and differentiation of many cell types
cytokines
receptor tyrosine kinases transmit a hormone signal to __, a GTPase switch protein that passes on the signal to downstream components
Ras
__ __ is a serine/threonine kinase that can translocate into the nucleus and phosphorylate many different proteins including transcription factors that regulate gene expression and mitosis.
MAP kinase
The major mammalian MAP kinases are __, __, and __
JNK, ERK, p38
The MAP kinase pathway is highly __ meaning it can be found in several eukaryotic organisms
conserved
The __-__ pathway is crucial in inflammation and is activated by TNF alpha.
NF-kappa B
Phosphorylation-dependent protein degradation regulates __-__
NF-kB
Interaction of different signaling pathways permits fine-tuning of __ __
cellular activities
The __ signaling pathway involves the frizzled receptor and the disheveled pathway to make B-catenin
Wnt
The __ signaling pathway involves the patched/smoothened receptor to make Ci
hedgehog
Hedgehog signaling in vertebrates is involved in __
cilia
Hedgehog gradient elicits different cell fates in the __ __ tube
vertebrate neural
The __ signaling pathway involves the notch receptor and the gamma secretase pathway to make cytosolic domains
delta
The proteolytic cleavage of __ __ __ (APP) causes the buildup of amyloid plaques which leads to __ __
amyloid precursor protein, alzheimer's disease
__ and __ Work Together to Maintain Stable Blood Glucose Levels
insulin, glucagon
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