Test 4 immunology

Chapter 14 hypersensitive 2
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Which of the following are matched correctly?type I hypersensitivity: IgE type II hypersensitivity: IgG type III hypersensitivity: immune complexed. type IV hypersensitivity: delayed type hypersensitivity.Which of the following is not mediated by antibodies?type IV hypersensitivity.__________ hypersensitivity reactions interact with soluble epitopes and NOT cell-surface associated epitopesType I and IIIAdaptive immune responses targeted at infections by helminth worms and other parasitic multicellular animals employ all of the following except _____.CD8 T cellsDuring a primary immune response IgM sometimes switches to IgE. Which of the following best describes the consequence of this early switch?The IgE produced would have low affinity for antigen.Which of the following regarding FcεRI is false?It is a low-affinity receptor involved in type I hypersensitivity reactionsThe sheddase __________ cleaves FcεRII on the cell surface, resulting in the production of soluble and membrane-bound forms of FcεRII.ADAM10Multicellular parasitesare most effectively cleared by type 2 immunity.Chapter 15 transplantation immunologyChapter 15 transplantation immunology----are universal recipients who can receive blood from any donor but can donate only to individuals with their blood typeAB RhD+Select the INCORRECT statement concerning the characteristics of blood donations and transfusions that enable their extensive use for transplantation purposes.Only the ABO antigens need to be compatible between donor and recipientIn routine blood transfusions, which of the following does NOT need to be matched for a successful transfusion?O antigensWhile MHC matching is important for transplantation, ABO blood group matching is also critical because:Complement will cause rapid lysis of ABO mismatched cellsBecause T cells are essential in graft rejection, nude mice, which lack a thymus:The direct pathway of allorecognition involves interaction of__________, whereas the indirect pathway of alloreaction involves interaction of __________.recipient T cells with allogeneic HLA molecules on donor dendritic cells; recipient T cells with peptides of allogeneic HLA molecules on recipient dendritic cells.Kidney transplant infiltrates show both CD4+ andCD8+ T cells. This suggests that to reduce graft rejectionNone of the above are viable treatments.Which of the following causes the T-cell receptors to be internalized and unavailable for antigen recognition?OKT3Steroid receptors are complexed withHsp90 in the cytoplasm.Graft-versus-host disease (GVHD) is a consequence ofmature T lymphocytes from the donor mounting an immune response against tissue of the recipientWhich of the following best explains why a bone marrow donor needs to be HLA-matched to the recipient?The recipient's MHC molecules mediate positive selection of thymocytes in the thymus that interact with donor-derived MHC molecules in the periphery.chapter 16 part 1ch 16 part1Some forms of autoimmune disease involve IgE autoantibodiesfalseMost autoimmune diseases involve a breach of T-cell tolerance.trueIndividuals who have two defective alleles of the AIRE gene______exhibit symptoms of autoimmunity at a young age.All of the following describe mechanisms that influence tolerance to self antigens except____Negative selection of T cells in the peripheral circulation;Chapter 16 part2Chapter 16 part 2Which of the following is an example of a type II autoimmune response?myasthenia gravisWhich of the following is the cause of red blood cell deficiency in autoimmune hemolytic anemia?hemolysis by assembly of membrane-attack complexesWhich of the following is NOT a characteristic of Graves' disease?elevated thyroid-stimulating hormoneWhich of the following describes myasthenia gravis?The neuromuscular junction is impairedThyroid-stimulating hormone is made in the __________ and induces therelease of thyroid hormones after proteolytic processing of __________.pituitary gland; thyroglobulinGraves' disease causes __________, whereas Hashimoto's disease causes__________.hyperthyroidism; hypothyroidismThe reason why babies born to mothers with Graves' disease suffer passively from the disease for only a short while after birth is thatonly antibodies, and not the B cells making the autoantibodies, cross the placenta.