Chapter 13: Intracellular Membrane Traffic

There are at least two layers to clathrin coated vesicles. Which proteins make up each layer and what is the overall function of each layer?
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- binding of v-SNARE to t-SNARE leads to helical domains wrapping around one another
- forms 4-helix bundle termed a tran-SNARE complex
-Ratcheting of helical domains of v-and t-SNARES removes water from between the membranes
- contact between the two cytosolic leaflets of the membranes forms a stalk and exchange of phospholipids
- membrane fused
Image: Describe the mechanism by which SNARE proteins facilitate vesicle fusion. (see figure 13-19).