Flow of renal blood supplyAbdominal aorta, renal artery, segmental artery, interlobar artery, arcuate artery, cortical radiate artery, afferent arteriole, glomerulus, efferent arteriole, peritubular capillaries, cortical radiate vein, arcuate vein, interlobar vein, renal vein, inferior vena cavaazotemia (renal failure)Increases BUN levels, nitrogenous waste in bloodUremiatoxic effects as wastes accumulateIncreased GFR levelsurine output rises. leads to dehydration, electrolyte depletion and imbalancesDecreased GFR levelsurine output decreases. wastes reabsorbed and or not excretedJuxtaglomerular Cells (JC)Monitors Blood PressureMacula DensaMonitors and adjusts blood pressure and NaCl content of filtrateMacula DensaWhen excess NaCl reaches macula densa in distal tubule of JGA, afferent arterioles are vasoconstricted and GFR drops
•Low NaCl causes afferent arteriole vasodilation, and GFR risesHeart secretes atrial natriuretic peptide (ANP) andventricular natriuretic peptide (BNP) in response to increased blood volume and pressure
•Increase excretion of sodium and water excretion
•Dilates afferent arterioleAngiotensin II causes•Vasoconstriction of afferent and efferent arterioles
•Secretion of ADH from the hypothalamus
•Secretion of Aldosterone from the adrenal cortex•Antidiuretic Hormone (ADH or Vasopressin) causes•Increase in thirst
•Vasoconstriction
•Retention of water only
•ADH is called the freshwater hormoneAldosterone causes•sodium and water retention
•Aldosterone is called the saltwater hormone
•Potassium loss
•Increase in blood volume
•Increase in blood pressureAzotemiaAzotemia