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HEMATOLOGY - SEMIFINAL EXAMINATION

Terms in this set (79)

Diapedesis
- The locomotion/movement of blood cells to the tissues via the unruptured wall of the blood vessel is known as
Opsonin
- Any substance, either specific antibodies or a complement that enhance phagocytosis and increases chemotaxis
Complement (C3b),Fc of IgG3
- A neutrophil expresses receptor for
Myeloblast, Promyelocyte, Myelocyte
- Which of the following is present in the mitotic pool of the bone marrow?
Myeloblast, Promyelocyte, and Myelocyte are capable Metamyeloblast and N-Band are not capable
- All of the following cells are capable of mitosis EXCEPT
4-5 days
- How long does a neutrophil stay in the tissues?
S = 3 NS=1
What is the ratio of nonspecific to specific granules in the granulocytes?
Peptidase, Collagenase, Muramidase, Lactoferrin, Lysozyme, Basic Protein - All of the following are components of the Specific granules EXCEPT
...
Peroxidase, Esterase, Sulphated muco, Lysozyme, B-galactosidase, Aryl sulfatase, Basic Protein (hindi kasama ang Alkaline phosphatase kasi nasa plasma ng neutrophil)
-The following are present in the Non-specific granules EXCEPT
Myeloperoxidase
- What specific enzyme is involved in the formation of reactive peroxide halide that is used by WBC to kill microorganisms?
Variation in shape
-What red cell morphologic abnormality is described by the term "poikilocytosis"?
Compatible to azures, Non-specific, Red/Purple Color
- Which of the following is characteristic of primary granules?
10 hours in Peripheral Blood
- What is the approximate amount of time a granulocyte spends in circulation before migrating into the tissues?
Methemoglobin
- A derivative of hgb in which ferrous iron is oxidized to ferric state resulting to inability to combine with oxygen.
Reticulocyte
- A Supravital stain must be used to demonstrate the presence of
Reticulocyte
-Stage of maturation where there is no more hemoglobin synthesis.
Reticulocyte
-During this stage the nucleus is extruded from the cell.
Metarubricyte/Orthochromic normoblast/Erythroblast
- At this time, we see the accumulation of hemoglobin due to its continued synthesis.
Reticulocyte
Stage of maturation where there is no more hemoglobin synthesis.
Reticulocyte
During this stage the nucleus is extruded from the cell.
Metarubricyte/Orthochromic normoblast/Erythroblast
At this time, we see the accumulation of hemoglobin due to its continued synthesis.
Reticulocyte
Slightly smaller nucleus with slight chromatin condensation; increased cytoplasm and intensely blue
(RNA abundance); no granules and no nucleoli present.
...
Rubriblast/Pronormoblast/Proerythroblast
Nucleus is large with fine chromatin and nucleoli; cytoplasm is scant and basophilic.
Metarubricyte/Orthochromic normoblast/Erythroblast
Dark, opaque nucleus; gray-red cytoplasm (trace blue). The nucleus has become pyknotic and there is
abundant acidophilic hemoglobin.
Monocyte
This blood cell is the parent cell of the Monocytes.
Myeloblast or Rubriblast
basophilic cytoplasm
Rubricyte
capable of mitosis
Myeloblast or Rubriblast
has a visible nucleoli
Rubricyte
presence of hemoglobin
Shift to Right, Low Affinity to O2
Increase in PCO2
Shift to Right, Low Affinity to O2
Increase in Temperature
Shift to Right, Low Affinity to O2
Increase in 2,3-DPG
Shift to Right, Low Affinity to O2
Alkalosis
Shift to left, High Affinity to O2
Decrease in PCO2
Shift to left, High Affinity to O2
Decrease in Temperature
Shift to left, High Affinity to O2
Decrease in 2,3-DPG
Shift to left, High Affinity to O2
Acidosis
High Affinity to O2
High Altitude
Low Affinity to O2
Low altitude
Poikilocytosis
Variation in shape of RBC's
Methemoglobin
A derivative of hgb in which ferrous iron is oxidized to ferric state resulting to inability to combine with oxygen.
Supravital/Wright Stain
A stain for the demonstration of reticulocytes
Transferrin/Siderophilin
Which of the following is/are iron transport protein?
Ferritin
In the body, what is considered as long term storage of iron?
Ferritin Aggregates/Sideroblast
Unused iron in hemoglobin formation is stored in RBC. The RBC in the bone marrow then has ferritin granules known as
Hgb A
Hemoglobin with 2 Alpha and 2 Beta chains
Hgb A2
Hemoglobin with 2 alpha and 2 delta chain
Bone Marrow
At birth into adulthood, major blood cell production is confined in
Wright Stain
The most widely used stain for hematological smear.
heme and globin
Hemoglobin synthesis requires the coordinated production of ______ and ________.
Mitochondria
Heme is synthesized in a complex series of steps involving enzymes in the
16
The genes that encode the alpha globin chains are on chromosome ____
11
Those that encode the non-alpha globin chains are on chromosome
Rubricyte
Young red cells that are usually slightly larger than the normocytes and stain polychromatophilic.
Rubricyte
The last stage in RBC maturation series that is capable of cell division
Myeloblast, Promyelocyte, Myelocyte, N-Band, Monocyte, Lymphocyte
-The correct order in WBC maturation series
Eosinophil
- What specific WBC increases in hookworm infection?
Megakaryoblast, Promegakaryocyte, Megakaryocyte
Correct stages in platelet maturation
Hemoconcentration
Prolonged application of tourniquet may result to:
Heme-heme interaction
It regulates the affinity of hemoglobin to oxygen.
Heme
This is composed of iron and protoporphyrin IX . _____________________.
2.68 mL
Two (2) grams of hemoglobin can carry how many ml of oxygen?
Ferrochelatase
The enzyme responsible in the insertion of iron into protoporphyrin ring.
Ferritin
The iron is delivered to maturing RBC by a specific transport protein known as
Decreases
- As pH becomes more acidic, hemoglobin's affinity for oxygen
CFU-BL, CFU-TL
The multipotential stem cell CFU-L gives rise to
Prorubricyte
T he cells seen in the peripheral smear has basophilic cytoplasm, large nucleus and are non granular.This cell is
Low affinity
- When there is increase hydrogen ions, hemoglobins affinity for oxygen
P 50 or Partial Pressure
- It refers to the pressure at which the hemoglobin is half saturated with oxygen.
4:1
- What is the N:C ration of Rubricyte?
8:1
- What is the N:C ratio of Rubriblast? (Pls. refer to choices in #88)
Iron
- What is the substance needed in RBC maturation and differentiation.
Vitamin E
-What is the substance needed in cell division?
Yolk sac/2nd-9th week/Mesoblastic/Megaloblastic
- Where does the primitive RBC's first developed?
Potassium ferricyanide
- Component of cyanmethhemoglobin reagent that oxidizes iron from ferrous to ferric.
Non-ionic detergent
- Component of HICN reagent that limit turbidity due to paraproteins.
Supravital stain
-Process of staining reticulocytes
Rubricyte
During this stage in erythropoiesis, hemoglobin synthesis begins.
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