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What is a synthetic prostaglandin? What's the side affect?
Antidote for NSAID induced gastritis.
Misoprotol: causes diarrhea
Which compounds are used as an analgesic?
Aspirin, Indomethacin, Naproxen, Piroxialam
What is the enzyme of importance in the protaglandin biosynthesis pathway that controls the production of cyclic endoperoxides?
Cyclic endoperoxides are converted into what three products?
Thromboxanes, Prostaglandins, and Prostacyclins
What is the affect of prostaglandins released in the stomach?
increased muscous secretion
reduced acid secretion
Inflammation in the immune system
What is the affect of blocking the production of cyclic endoperoxides by inhibition of cyclo-oxygenase (COX)?
mucous secretion in the stomach decreases
acid secretion increases
results in gastritis
Cyclo-oxygenase is 2 enzymes? what are adverse affect are they responsible for?
COX I enyzme inhibitor: gastritis
COX II enzyme inhibitor: stops inflammation
What's the mode of action for aspirin?
it blocks the migration of PMNs into the tissue
blocks production arachidonic acid
What are the 2 molecules resulting from aspirin metabolism? What is the significance?
acetate (prevent plalet aggregation) and salicylate
What is a major difference between acetomenophen and aspirin?
acetomenophen is NOT an anti-inflammatory agent
What is a therapetic strategies for aspirin to avoid bleeding?
Given patient's aspirin products to relieve pain and disease; DVD; strategy is to keep a low dose by given it every OTHER day therapy (12 pills/day)
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