Autism

Autism Spectrum disorder DSM5 criteria
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Autism Spectrum disorder DSM5 criteria
A. Impaired social relations,
B. repetitive behavior
c. early in developmen
d. significant impairmen
e. not only intellectual disability
Increasing Autism Rates
1 in 44 CDC 2021
5:1
https://www.cdc.gov/media/relea
ses/2020/p0326
prevalence
cdc.gov/nchs/
Why is Autism increasing?
The number of children diagnosed is increasing.
-Reflecting that field is getting better at identifying and understanding it.
(Diagnoses of mental disorders are more accurate).
maybe toxins, infections, genes/epigenetics

NOT vaccine
NOT Measles MMR Vaccine
NOT Mercury poisoning from Early research was fraudulent
MMR vaccine
thimerosal
-
mercury based preservative
-
removed
2001 still rates going up
Antidepressant in Pregnancy could Raise Autism Risk
ndafter factoring out depression
SSRI in 2
or 3
trimester raises ASD risk even
rd
SSRI and Autism
almost 2 times Risk but
Meta analysis suggests there may be
contribution SSRI to increase
risk about 1.84 times ,
but maybe due to confounding variables
Toxic Endocrine Disruptors and Autism
MetanalyticASD associated with all chemicals
Microglia
!
inc tended garden
-
synaptic pruning
Microgliadeveloping brain like un
-
synaptic pruning(
/dec) pruning disruptions
Autism etiology model (Wolfe)
Mom's infection, antibodies, heavy metals,vinyl, high Folate, low Vitamin D, electromagnetic
radiation?
some Autism Neuropathologies
Excess Growth
Prefrontal Cortex mirror neurons deficient
area
Connectivity changes (over , under) Computational models
Premotor Fusiform Face
Mirror Neuron dysfuction in Autismcorrelated with severity.Less ! activeFusiformFace Areaooking at facesEarly Intervention AutismSubjects:18 months+ Method:- Early Start Denver - social interaction- 2 yearsE.g. reward for eye contact or word for toy Result: 30% re-diagnosed less severe autismAutism Neurofeedback, game tunes the brainKids with ASD diagnosis play game in MRI affect connectivity