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Terms in this set (10)
Syndromes in which groups of endocrine tumors appear together in the same patient
Contributes to a group of "heritable" syndromes characterized by:
> Inherited diseases
> Tumors in Endocrine Glands
- pancreas, thyroid, parathyroid, pituitary, adrenal
> Over Production of Hormones
> MEN1, MEN2A, MEN2B
Contributes to a group of "heritable" syndromes characterized by:
> Inherited diseases
> Tumors in Endocrine Glands
- pancreas, thyroid, parathyroid, pituitary, adrenal
> Over Production of Hormones
> MEN1, MEN2A, MEN2B
aka Wermer syndrome
- Inherited as an autosomal dominant pattern
- causes tumors in pancreas, pituitary, and parathyroid
- Mutations located to the MEN1 gene, encodes Menin (tumor suppressor)
- ~ 10% of MEN1 mutations arise de novo; term _____ applied
90% exhibit hyperparathyroidism:
- most common feature of MEN1
- first clinical manifestation
- MEN1 is a rare cause of hyperparathyroidism
- Inherited as an autosomal dominant pattern
- causes tumors in pancreas, pituitary, and parathyroid
- Mutations located to the MEN1 gene, encodes Menin (tumor suppressor)
- ~ 10% of MEN1 mutations arise de novo; term _____ applied
90% exhibit hyperparathyroidism:
- most common feature of MEN1
- first clinical manifestation
- MEN1 is a rare cause of hyperparathyroidism
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