Final Endo: CH. 22 - Multiple Endocrine Neoplasia

What is multiple endocrine neoplasia?
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Terms in this set (10)
Syndromes in which groups of endocrine tumors appear together in the same patient

Contributes to a group of "heritable" syndromes characterized by:
> Inherited diseases

> Tumors in Endocrine Glands
- pancreas, thyroid, parathyroid, pituitary, adrenal

> Over Production of Hormones

aka Wermer syndrome

- Inherited as an autosomal dominant pattern

- causes tumors in pancreas, pituitary, and parathyroid

- Mutations located to the MEN1 gene, encodes Menin (tumor suppressor)

- ~ 10% of MEN1 mutations arise de novo; term _____ applied

90% exhibit hyperparathyroidism:
- most common feature of MEN1
- first clinical manifestation
- MEN1 is a rare cause of hyperparathyroidism