Endocrine Pharm III

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Big Picture of Endocrine Disorder Drugs
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Terms in this set (4)
Big Picture of Endocrine Disorder Drugs
-Thyroid Disoders
-Hypothalamic Diabetes Insipidus
-Acromegaly
-Cushing's
-Addison's
Synthetic Thyroid Hormone Preparations:
Levothyroxine
Use: Hypothyroidism
Administer: PO(99% time)/ IV in myxedema coma
1. Food decrease absorption so take on empty stomach
2.Separate from certain drugs by 5 hours
-H2 Receptor Blockers, PPI's, Sucralfate, Calcium, Magnesium, Aluminum, Iron, Cholestyramine
Adverse: Only if oversode: Thyrotoxicosis
-s/s: tachycardia, angina, tremor, nervousness, insomnia, hyperthermia, sweating
Cbronic OD: increased riks of atrial fibrillation, acceleration of Warfarin breakdown, excellerate bone loss
Thionamides: Suppress synthesis of thyroid hormones
-Propylthiouracil (PTU)
-Methimazole: fist line
Use: Hyperthyrodism
Adverse: avoid pregnacy/breast feeding, agoind hypothyrodism
Agranulocytosis: rare but serious, decrease type of WBC (neutrophils)
-S/S: sore throat, fever
Radioactive
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