Week 15: Purine and Pyrimidine Synthesis

Purine biosynthesis starts with the activation of a 5-carbon sugar. In this initial reaction, ribose 5-phosphate is converted into which of the following compounds?
- 5- methyl thymidine
- Inosine monophosphate
- Glucose 6-phosphate
- 5- phosphoribosyl pyrophosphate (PRPP)
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A newborn is suspected of a defect in nucleotide synthesis due to the elevation of orotic acid. It is determined there is no deficiency in orotate phosphoribosyltransferase. Based on this presentation, which of the following enzymes is most likely deficient?
- Carbamoyl phosphate synthetase II (CPSII)
- Thymidylate synthase
- Ornithine transcarbamylase
- Glutamyl amidotransferase