Cushing's syndrome may be
Exogenous or endogenous
Most common form of exogenous
Corticosteroid drugs used to treat other diseases
Cushing disease is caused by
Excess secretion of ACTH by the pituitary, often result in a small pituitary adenoma
The major cause of endogenous Cushing's syndrome
Most common pre-menopausal women
Other causes of Cushings syndrome
Adrenocortical tumors and nonpitutary ACTH-producing tumors
Hypercortisolism may present as
obesity, hypertension, and diabetes mellitus
Obesity is centripetal, and extremities appear wasted
Fat deposits also causes a characteristic
Buffalo hump moon facies, and supraclavicular pads
The most specific signs are
proximal muscle weakness and pigmented stria more than 1cm wide
Patients may present with
back ache and headache
Common presenting symptoms
oligomenorrhea amenorrhea erectile dysfunction
Disorders calcium metabolism may cause
osteoporosis vertebral fracture hypercalciuria and kidney stones
wound healing acne easy bruisability and superficial skin infections
emotional lability to psychosis
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