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Normal Skin Flora & Bacterial Infections of the Integumentary System

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Diversity of the skin @ different body sites
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Terms in this set (50)
Diversity of the skin @ different body sites
• Face
High density of sebaceous glands
Hair & eccrine glands
Environmentally exposed

• Palm (dry)
Thick stratum corneum
Hairless
High density of eccrine glands

• Axilla (moist)
Apocrine glands
High density of hair
Oclluded, humid environment
Image: Diversity of the skin @ different body sites
Functional associations w/ communities on the skin
• AMP = anti-microbial peptides
Image: Functional associations w/ communities on the skin
Models of dysbiosis
a) Driven by Microbial Communities
b) driven by host biology/pathology
Image: Models of dysbiosis
Important colonizers*
•#1 Coagulase negative staphylococci, e.g.,
→→ Staphylococcus epidermidis: no associated skin disease despite large numbers on skin but involved in IV catheter infections & prosthetic device infections.

•Propionibacterium sp.: produce fatty acids which inhibit most bacteria including most Gram-negatives (except Acinetobacter)* Propionibacterium acnes associated with acnes & opportunistic infections.

•Staphylococcus aureus - small #s in moist areas; larger #s on cutaneous surfaces of diabetics, injection drug users, & some health care workers.
Less impt colonizers
• Viridans streptococci & peptostreptococci (anaerobic cousins)

• Corynebacterium spp.

• Brevibacterium spp. (cheesy foot odor)

• Propionibacterium spp. (but important for fatty acid production).

• Acinetobacter spp. (Gram negative) (no associated skin disease)

• Clostridium perfringens found in about 20% of healthy adults