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Surface proteins clumping factor and firbrinonectin binding proteins
Clumping factor binds fibrinogen. Fibrinonectin binding proteins bind fibrinonectin. These playe key role in early infection
Protein A binds the Fc portion of IgG, leaving the Ag binding site turned around, protein A contributes to the virulence as an antiphagocytic factor.
Most important determinant of S. aureus versus other staphylococci. Coagulase activates prothrombin without usual proteolytic cleavages to form a fibrin clot.
Alpha toxin inserts into host cell membranes to form pores. It lyses the membranes of host cels. Secreted by most S aureus strains, but not by coagulase negative cocci
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