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track 4, pathogens

Surface proteins clumping factor and firbrinonectin binding proteins

Clumping factor binds fibrinogen. Fibrinonectin binding proteins bind fibrinonectin. These playe key role in early infection

Protein A

Protein A binds the Fc portion of IgG, leaving the Ag binding site turned around, protein A contributes to the virulence as an antiphagocytic factor.


Most important determinant of S. aureus versus other staphylococci. Coagulase activates prothrombin without usual proteolytic cleavages to form a fibrin clot.

Alpha toxin

Alpha toxin inserts into host cell membranes to form pores. It lyses the membranes of host cels. Secreted by most S aureus strains, but not by coagulase negative cocci


Exfoliatin splits intraepidermal junctions.

Superantigen toxins

SAgs are secreted proteins that stimulate systemic effect after absorption from GI track or ingestion. These bind MHC II without processing and cause massive cytokine release.

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