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33 terms

Erythrocyte Morphology

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Macrocytosis
Size: an increase of larger than normal, usually immature polychromatic RBC
Cause: response to anemia
Microcytosis
Size: an increase in the number of RBC's smaller in diameter than normal
Cause: decreased MCV
normocytic
Size: normal sized erythrocytes
Cause: healthy..
MCV
mean corpuscular volume
normochromasia
Color: Mature cell that stains pink in color. Area of central pallor, in mammals.. Reptiles, amphibians and birds have a nucleus
Cause: again healthy
polychromasia
Color: cells that have a bluish tint due to remaining organelles in cytoplasm when stained with NMB =reticulocytes
Cause: anemia
hypochromasia
Color: lack of decreased in staining intensity. Due to decrease in cellular hemoglobin
Cause: iron deficiency
acanthocyte
Shape: "spur cells"
cells with irregularly shaped margins/projections from the cell wall
Cause: liver disease, hemangiosarcoma, renal disease, alterations in cholesterol, phospholids
cancer of blood vessels
hemangiosarcoma
crenation
Shape: cells with spiky projections even with distribution around the cell
drepanocytes
Shape: 'sickle cells' normal in deer and angora goats
Cause: healthy in deer and A. Goats
keratocytes
Shape: 'helmet cells' cell appears to have an air bubble (two horn like projections)
Cause: neoplasia, kidney disorders, liver disorders and hormone deformity.
anulocytes
Shape: bowl shaped RBC result in loss of membrane flexibility cannot return to normal shape
cause: caused by going through capillaries
echinocyte
Shape: 'burr cells' spine like projections from all surfaces of the cell
cause:observed in horses after exercising or with renal disease, dogs with lymphosarcoma
codocyte
Shape: 'target cells' contained in central round portion of hemoglobin inside the area of central pallor
cause: usually due to liver disease may be precursor to acanthocytes
leptocyte
Shape: large thin RBC that is folded or misshapen due to increased membrane of decreased volume
Cause: found in regenerative anemia
stomatocyte
Shape: form of leptocytes, large thin cell that warps when passing through small blood vessels
cause: inherited disorders seen in dogs
(looks like golden crisps.. (I) )
dacrocyte
Shape: 'tear cell'
tear drop shaped cell
Cause: myelofibrosis and certain other myeloproliferative diseases.
spherocyte
Shape: smaller dense dark staining lack in central pallor. No longer maintains disc shape.
Cause: indicates immune mediated damage IMHA-immune mediated hemolytic anemia
IMHA
immune mediated hemolytic anemia
schistocyte
fragmented erythrocytes
Cause: suggestive mechanical damage or vascular occlusion. DIC
DIC
Shape: Disseminated intravascular coagulation
rouleaux
Shape: erythrocytes appearing as stack of coins or rows
normal in horses
cause: inflammatory disease alterations of plasma proteins
poikilocytosis
Shape: general presence of a variation in cell shape.
Cause: mishandling the sample
agglutination
Shape: amorphous clumping or erythrocytes
Cause: typically associated with immune disease, do not use automated RBC counting or sizing as this will just count group as just one cell when there are many....
anisocytosis
Shape: variation in size of RBC's normal amount varies with species
Cause: large or small cells mild moderate or marked.
Howell jolly bodies
Inclusions: erythrocytes that retain small round nuclear fragments. dark staining inter cellular bodies. removed by the spleen
Cause: noted in splenic disorders, regenerative animia
heinz bodies
Inclusions: small round areas of denatured hemoglobin attached to the cell membrane. dyes purple when stained with NMB
Caused: due to oxidation denaturing of hemoglobin in RBC commonly found in cats
basophilic stippling
Inclusions: small blue staining granules RNA within the erythrocyte seen with diff quick
Cause: usually from ruminant regenterative anemia may be lead poisoning toxicity
nucleated red blood cells
Inclusions: (nRBC) slightly darker than mature RBC darker staining cytoplasm retained nulceaus
Cause: released in response to anemia, normal in birds and reptiles
reticulocyte
Inclusions: (polychromatophil) immature RBC that has organelles that are lost when cell matures
Cause: NMB staining when found, not nice round dots just scattered dots..
ghost cells
artifact: red blood cell which has had all of its cytoplasmic contents removed by cell lysis so only its outer membrane remains
cause: diff quick stained outlined erythrocyte not pink... looks improperly stained...
stain precipitate
artifact: appears as purple granules
cause: just an artifact, junk