Size: an increase of larger than normal, usually immature polychromatic RBC Cause: response to anemia
Size: an increase in the number of RBC's smaller in diameter than normal Cause: decreased MCV
Size: normal sized erythrocytes Cause: healthy..
mean corpuscular volume
Color: Mature cell that stains pink in color. Area of central pallor, in mammals.. Reptiles, amphibians and birds have a nucleus Cause: again healthy
Color: cells that have a bluish tint due to remaining organelles in cytoplasm when stained with NMB =reticulocytes Cause: anemia
Color: lack of decreased in staining intensity. Due to decrease in cellular hemoglobin Cause: iron deficiency
Shape: "spur cells" cells with irregularly shaped margins/projections from the cell wall Cause: liver disease, hemangiosarcoma, renal disease, alterations in cholesterol, phospholids
cancer of blood vessels
Shape: cells with spiky projections even with distribution around the cell
Shape: 'sickle cells' normal in deer and angora goats Cause: healthy in deer and A. Goats
Shape: 'helmet cells' cell appears to have an air bubble (two horn like projections) Cause: neoplasia, kidney disorders, liver disorders and hormone deformity.
Shape: bowl shaped RBC result in loss of membrane flexibility cannot return to normal shape cause: caused by going through capillaries
Shape: 'burr cells' spine like projections from all surfaces of the cell cause:observed in horses after exercising or with renal disease, dogs with lymphosarcoma
Shape: 'target cells' contained in central round portion of hemoglobin inside the area of central pallor cause: usually due to liver disease may be precursor to acanthocytes
Shape: large thin RBC that is folded or misshapen due to increased membrane of decreased volume Cause: found in regenerative anemia
Shape: form of leptocytes, large thin cell that warps when passing through small blood vessels cause: inherited disorders seen in dogs (looks like golden crisps.. (I) )
Shape: 'tear cell' tear drop shaped cell Cause: myelofibrosis and certain other myeloproliferative diseases.
Shape: smaller dense dark staining lack in central pallor. No longer maintains disc shape. Cause: indicates immune mediated damage IMHA-immune mediated hemolytic anemia
immune mediated hemolytic anemia
fragmented erythrocytes Cause: suggestive mechanical damage or vascular occlusion. DIC
Shape: Disseminated intravascular coagulation
Shape: erythrocytes appearing as stack of coins or rows normal in horses cause: inflammatory disease alterations of plasma proteins
Shape: general presence of a variation in cell shape. Cause: mishandling the sample
Shape: amorphous clumping or erythrocytes Cause: typically associated with immune disease, do not use automated RBC counting or sizing as this will just count group as just one cell when there are many....
Shape: variation in size of RBC's normal amount varies with species Cause: large or small cells mild moderate or marked.
Howell jolly bodies
Inclusions: erythrocytes that retain small round nuclear fragments. dark staining inter cellular bodies. removed by the spleen Cause: noted in splenic disorders, regenerative animia
Inclusions: small round areas of denatured hemoglobin attached to the cell membrane. dyes purple when stained with NMB Caused: due to oxidation denaturing of hemoglobin in RBC commonly found in cats
Inclusions: small blue staining granules RNA within the erythrocyte seen with diff quick Cause: usually from ruminant regenterative anemia may be lead poisoning toxicity
nucleated red blood cells
Inclusions: (nRBC) slightly darker than mature RBC darker staining cytoplasm retained nulceaus Cause: released in response to anemia, normal in birds and reptiles
Inclusions: (polychromatophil) immature RBC that has organelles that are lost when cell matures Cause: NMB staining when found, not nice round dots just scattered dots..
artifact: red blood cell which has had all of its cytoplasmic contents removed by cell lysis so only its outer membrane remains cause: diff quick stained outlined erythrocyte not pink... looks improperly stained...
artifact: appears as purple granules cause: just an artifact, junk