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Terms in this set (44)

--Secondary stage of syphilis usually appears a few weeks (or up to 6 months) after development of the chancre, when dissemination of T pallidum produces systemic signs (fever, lymphadenopathy) or infectious lesions at sites distant from the site of inoculation.

--Most common manifestations are skin and mucosal lesions.

--Skin lesions are nonpruritic, macular, papular, pustular, or follicular (or combinations of any of these types, but generally not vesicular) and generalized; involvement of the palms and soles occurs in 80% of cases.
--Annular lesions simulating ringworm may be observed in dark-skinned individuals.

--Mucous membrane lesions may include mucous patches, which can be found on the lips, mouth, tongue, throat, genitalia, and anus.

--Specific lesions—condylomata lata—are fused, weeping papules on the moist areas of the skin and mucous membranes and are sometimes mistaken for genital warts.

--Mucous membrane lesions are HIGHLY infectious.

--Meningeal (aseptic meningitis or acute basilar meningitis), hepatic, renal, bone, and joint invasion may occur, with resulting cranial nerve palsies, jaundice, nephrotic syndrome, and periostitis.

--Alopecia (moth-eaten appearance) and uveitis may also occur.

--The serologic tests for syphilis are positive in almost all cases.

--The moist cutaneous and mucous membrane lesions often show T pallidum on dark-field microscopic examination.

--There may be evidence of hepatitis or nephritis (immune complex type) as circulating immune complexes are deposited in blood vessel walls.

--Skin lesions may be confused with the infectious exanthems, pityriasis rosea, and drug eruptions.

--Visceral lesions may suggest nephritis or hepatitis due to other causes.