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Acute rheumatic fever

Occurs 1-4 weeks after tonsillitis; group A Beta-hemolytic streptococci; common in children 5-15 years

Rheumatic heart disease

Occurs many years after rheumatic fever; often asymptomatic; fibrotic, deformed, calcified lines of closure on valve leaflets; mitral valve > aortic valve

major jones criteria

polyarthritis; erythema; subcutaneous nodules; chorea; carditis


Cardititis of rheumatic fever; serous effusions


Cardititis of rheumatic fever; heart failure


Cardititis of rheumatic fever; valvular damage

aschoff body

Focal interstitial myocardial inflammation; large myocytes (Anitschkow cells); multinucleated giant cells

rheumatic fever

Most common clinical presentation is migratory polyarthritis, lasting 2-3 weeks, accompanied by fever

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