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Biosci Lecture 3 - The cytoskeleton part I - Actin and Cell motility!!!!
Terms in this set (23)
The shape and structure of animal cells is dependant on an...
The internal skeleton is made up of...
proteins that form filamentous sheets and polymers
The cytoskeleton is a rigid framework that permits cells to acquire a...
certain shape for a particular function!
The cytoskeleton does more than just be a ____ internal framework.
Why is it that the cytoskeleton can play a fundamental role in many cellular processes like mitosis?
the cytoskeletal proteins are highly dynamic and undergo polymerisation and depolarisation as they please
Give another example of a function of the cytoskeleton other than being a static framework
They aid intracellular movement of cargo like membrane vesicles.
What are the 3 types of cytoskeletal filaments?
(note - only two are discussed in depth in the lectures)
These of which constitute a filamentous system.
Each filament system is composed as a polymer of assembled subunits. These units do what regularly to give cells flexibility for different structures as needed?
Assemble and disassemble
hence is reversible
Is actin a highly abundant and conserved protein encoded by a large family of genes?
What shape is the actin monomer?
The globular actin monomer (G-actin) can polymerise into a filamentous strand that winds around what to for a helix?
Describe the polarity of F actin
It has a polarity denoted with a positive and negative end.
Can new G-actin monomers be added to any side of F-actin?
But which side is polymerisation more efficient?
Polymerisation is regulated in vivo by what proteins?
Profilin and cofilin
Capping proteins that block G-actin addition
Actin has what separated by 2 lobes?
It also is 2 stranded to form a helix so it appears to repeat every what?
A deep cleft: ATP binding cleft
Polymers of actin organised into bundles and networks by what?
It can function by itself and serve as tracks for ATP powered myosin motor proteins which aid contractile function in muscles . True or false.
actin binding proteins
Microfilaments are important in organisation of what?
Plasma membrane and Microvilli
Myosins are what?
Actin-based motor proteins.
Describe how myosin moves along actin microfilaments.
By a series of conformational changes in the polypeptide coupled to ATP hydrolysis
What domain binds to actin and contains the catalytic site?
So what does the tail region do?
It interacts with cargo or other tails to form myosin filaments.
What ATP-driven myosin is responsible for the movement along actin filaments to enable contraction of skeletal muscles?
What does myosin V do?
Similarly moves along the filament but has a shorter tail and pulls membrane vesicles along the length of the filament.
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