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5 Written questions

5 Multiple choice questions

  1. PTHrP mutation in receptor
    Severe dwarfism.
    But aren't little people soooooo cute?
  2. Patterning ~> Skeletogenesis ~> Homeostasis
    Dyostoses Dysplasia
    Lethal Lethal 50% population problems
  3. Somites ~> Axial
    Lateral plate mesoderm ~> appendicular
    Cranial neural crest ~> craniofacial
    Monocyte ~> osteoclasts
  4. Runx2 ~> osteocalcin ~> osteoblast.
    Twist inhibits Runx2
    without it, no bone!
    (Runx2 is also for chondrocytes)
  5. Inactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet

4 True/False questions

  1. Cleidocranial dysplasiaRunx2 haploinsufficiency
    osteoblasts don't form and you have weak bones, no clavicle, and gap in skull

          

  2. ATF4Inactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet

          

  3. neurofibromatosisover-activated RSK2.
    Too much ATF4 ~> osteoclacin ~> too many osteoblasts

          

  4. Proliferation of chrondrocytesRunx2 ~> IHH ~> Proliferation
    Twist inhibits Runx2 as well
    However, IHH also induces PTHrP which inhibits IHH.
    This elongates the proliferative stage so you have enough cells before entering hypertrophy.

          

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