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5 Written questions

5 Multiple choice questions

  1. over-activated RSK2.
    Too much ATF4 ~> osteoclacin ~> too many osteoblasts
  2. Via sox9.
    Haploinsufficiency leads to dwarfism.
  3. PTHrP mutation in receptor
    Severe dwarfism.
    But aren't little people soooooo cute?
  4. Runx2 haploinsufficiency
    osteoblasts don't form and you have weak bones, no clavicle, and gap in skull
  5. From monocytes
    Osteoblasts secrete both OPG and RANKL
    OPG binds and inhibits RANKL
    RANKL causes osteoclast maturation

4 True/False questions

  1. Disorders of intramembranous bone formationDelay: Msx2, Runx2 haploinsufficiencies
    Acceleration: FGF, MSX2 activating mutations. twist haploinsufficiency

          

  2. Osteoblast DifferentiationFrom monocytes
    Osteoblasts secrete both OPG and RANKL
    OPG binds and inhibits RANKL
    RANKL causes osteoclast maturation

          

  3. Coffin-LowryInactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet

          

  4. ATF4Inactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet