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1st lines of defense in Non-specific Immunity
1. Physical and Mechanical Barriers
2. Biochemical Barriers
3. Epithelial Derived Chemicals
4. Bacterial Derived Chemicals
Physical and Mechanical Barriers
Skin, Mucous Membranes, Lining of Respiratory, GI, GU Tract, Low temperature on surface of skin
-Skin has pH of 3-5
-Sebaceous Glands secrete fatty acids & lactic acid
-Perspiration contains lysosomes
Bacteria Derived Chemicals
Normal flora in skin, GI, GU, and respiratory tract help digest, create, and absorb chemicals that we need. They also inhibit growth of more invasive bacteria
Functions of Inflammatory Response
1. Marshals resources within the vascular structure into surrounding affected tissue by releasing cells and fluids that isolate, destroy, and remove invaders.
2. It also promotes healing as it prepares the affected tissue for healing and repair.
5 Cardinal Signs of Inflammation
1. Calor = heat
2. Rubor = redness
3. Tumor = swelling
4. Dolor = Pain
5. Loss of Function
Inflammation involves orchestrated reactions of:
1. Vascular response and blood derived inflammatory mediators
2. Cell derived inflammatory mediators/ inflammatory cells
3. Mast cells
3 characteristics of vascular response
1. Blood vessel dilation
2. Increased vascular permeability and leakage from vessels.
3. White blood cell adherence to vessel walls and migration to the site of injury.
Sequence of vascular changes in inflammation
1. Phagocytes in circulation
Produced by blood proteins designated C1 - C9 with the goal to destroy and inactivate foreign antigens. Participates in virtually every inflammatory response
3 mechanisms to activate complement system
1. Antigen-Antibody complexes
2. Products released from bacteria
3. Components of other protein systems
Functions of complement
1. Opsonize Bacteria
2. Attract leukocytes to site
3. Act as anaphylatoxins/induce degranulation
4. Open pores in the PM of pathogens
5. Kill pathogens directly (MAC)
process by which fibrin strands create a meshwork that cements blood components together.
Functions of clotting system
1. Keep microorganisms where phagocytosis is high to prevent spread of infection
2. Form clots to stop bleeding
3. Prepare injured tissue for repair
2 pathways of Clotting System
1. Extrinsic (cuts, burns, crushing)
2. Intrinsic (toxins, kallikrein, collagen)
Function of Kinin System
2. Vascular permeability
4. Smooth Muscle Contraction
- 1st army in inflammation
- Arrive w/ in 90 minutes
- aka polymorphonuclear leukocytes (PMS)
- 10 day lifespan
-Found in MAST cells, platelets, basophils, eosinophils, neutrophils
-Causes Vasodilation and permeability of arterioles
-Constricts smooth muscles of large vessel walls
-Constricts bronchial smooth muscles & produces mucus
1. Sensitize blood vessels to effects of other inflammatory mediators
2. Produces free radicals
5. Vasodilation/Capillary Permeability
1. Smooth Muscles Contraction
2. Vascular Permeability
4. Happens late in inflammation
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