What are the 2 Pathways of Killin by Cytotoxic T cells?
-1st and most frequent is use of cytotoxic granules, released after attachment by exsocytosis
-Perforin polymerizes into transmembrane pores that increase membrane permeability
-Granzymes are serine proteases that pass into the cell and induce apoptosis (preventing lysis and releasing virus)
-2nd pathways uses interaction of CD178 (Fas Ligand) on CD8+ cell with CD95 (Fas) on host cell, using caspase proteolytic enzymes to activate apoptosis of target cells.