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Terms in this set (22)
when are these prenatal screening blood tests done? human chorionic gonadotropin, pregnancy-associated plasma protein A, and nuchal translucency ultrasound?
when are these prenatal screening blood tests done? Quad screen. MSAFP, hCG, unconjugated estriol, and inhibit A
free beta hCG
first trimester maternal blood test. more specific way of looking at hCG which is secreted by the trophoblast and peaks at 8-10 weeks. measured in 1st and 2nd trimester. high when trisomy 21 is present
PAPP-A (pregnancy associated plasma protein A)
first trimester maternal blood test. glycoprotein that is secreted by the trophoblastic tissue. measured in the first trimester. levels normally increased throughout pregnancy. low levels associated with chromosomal anomalies; specifically trisomy 21 an 18
maternal blood test done in the second trimester. produced first by the yolk sac and then by the fetal liver. found in the fetal spine, GI, liver, and kidneys. can be measured in the maternal blood or in the amniotic fluid. high or low depending on the cause.
evaluations for alfa-feto protein is based on --- to --- multiples of the median.
maternal serum AFP decreases/increases as the gestational age increases
AFAFP (amnionic fluid) increases/decreases as the gestational age increases
if the AFP is high/low it is associated with NTD's, abdominal wall defects, twins, GI obstruction
if the AFP is high/low it is associated with chromosomal anomalies, fetal demise, and molar pregnancies
omphalocele will cause the AFP to be high or low?
gastroschisis will cause the AFP to be high or low?
spina bifida will cause the AFP to be high or low?
anecephaly will cause the AFP to be high or low?
cystic hygroma will cause the AFP to be high or low?
enzyme found in nervous tissue that is leaked into the amniotic fluid ONLY when a neural tube defect is present.
MSAFP, hCG, unconjugated estriol, dimeric inhibin A
what are the four maternal blood tests included in the quad screen?
part of the quad scan. specific type of estrogen produced by syncytiotrophoblast. made in the fetal adrenal gland and liver. deconjugated in the placenta.
dimeric inhibin A
part of the quad screen. a protein secreted by the placenta. addition of this placental protein to the triple screen increase accuracy of down's syndrome detection.
---% of fetuses with trisomy 21 will have a thickened nuchal translucency
normal varies with gestational age of the nuchal translucency, over ---- mm is always abnormal
measure the nuchal translucency between --- and --- weeks