94 terms

Tumor Markers

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Neoplasm associated with Down Syndrome
ALL, AML
Neoplasm associated with Xeroderma pigmentosum, albinism
malanoma, Squamos cell carcinoma, basal cell carcinoma
Neoplasm associated with atrophic gastritis, pernicious anemia, post surgical gastric remnants
gastric adenocarcinoma
Neoplasm associated with tuberous sclerosis
astrocytoma, angiomyolipoma, cardiac rhabdomyoma
Neoplasm associated with actinic keratosis
squamos cell caricnoma of skin
Neoplasm associated with barrett's esophagus
esophageal adenocarcinoma
Neoplasm associated with plummer vinson syndrome
squamos cell carcinoma of esophagus
Neoplasm associated with cirrhosis
HCC
Neoplasm associated with ulcerative colitis
colonic adenocarcinoma
Neoplasm associated with paget's disease of bone
osteosarcoma, fibroscarcoma
Neoplasm associated with immunodeficiency states
malignant lymphomas
Neoplasm associated with aids
aggressive malignant lymphomas, Kaposi's sarcoma
Neoplasm associated with autoimmune diseases
lymphoma
Neoplasm associated with acanthosis nigricans
visceral malignancy, stomach, lung, breast, uterus
Neoplasm associated with dysplastic nevus
malignant melanoma
Neoplasm associated with radiation exposure
sarcoma, papillary thyroid cancer
abl
cml, tyrosine kinase, oncogene
c myc
burkitts lymphoma, transcription factor, oncogene
bcl-2
follicular/undiff lymphomas, anti apoptotic molecule, oncogene
erb-b2
breast/ovarian/gastric carcinomas, tyrosine kinase, oncogene
ras
colon carcinoma, GTPase, oncogene
L-myc
lung tumor, transcription factor, oncogene
N-myc
neuroblastoma, transcription factor, oncogene
ret
MEN 2a, MEN 2b, tyrosine kinase, oncogene
c-kit
GIST (gastrointestinal stromal tumor), cytokine receptor, oncogene
Rb
retinoblastoma/osteosarcoma, Rb blocks G1--> S phase of cell cycle, tumor suppressor gene
p53
most cancers, Li fraumeni syndrome, blocks G1-S phaseof cycle, tumor suppressor gene
BRCA 1
breast, ovarian, dna repair protein, tumor suppressor gene
BRCA 2
Breast cancer, DNA repair protein, tumor suppressor gene
p16
melanoma, tumor suppressor gene
APC
colorectal cancer, FAP, tumor suppressor gene
WT1
Wilms tumor, tumor suppressor gene
NF1
neurofibromatosis type 1, tumor suppressor gene
NF2
neurofibromatosis type 2, tumor suppressor gene
DPC
Pancreatic cancer, tumor suppressor gene
DCC
Colon Cancer, tumor suppressor gene
PSA
prostate specific antigen, BPH, prostatits, prostate carcinoma (only total PSA increase in prostate cancer, free PSA decrease) (free PSA increase in BPH)
prostatic acid phosphatase
prostate carcinoma
CEA
colorectal/pancreatic tumors, gastric, breast, thyroid medullary carcinomas
alpha feto protein
yolk sac/nonseminomatous germ cell testes tumors, HCC
B-hCG
hydatiform mole, choriocarcinomas, gestational trophoblastic tumors
CA-125
Ovarian, malignant epithelial
s-100
melanoma, schwannoma, langerhaans histiocytosis, astrocytomas
alkaline phosphatase
metasteses to bone, obstructive biliary disease, paget's dis. of bone
bombesin
gastric carcinoma, neuroblastoma, lung cancer
TRAP
hairy cell leukemia
CA-19-9
pancreatic adenocarcinoma
calcitonin
medullary thyroid carcinoma
HTLV-1
adult t cell leukemia/lymphoma
HBV/HCV
HCC
EBV
burkitts lymphoma, hodgkin's lymphoma, nasopharyngeal carcinoma
HPV
cervical carcinoma (16,18), penile/anal carcinoma
HHV8
Kaposi's sarcoma, body cavity fluid B cell lymphoma
HIV
CNS lymphoma
H pylori
Gastric adenocarcinoma, lymphoma
schistosoma haematobium
Squamos cell carcinoma of transitional epithelium of the bladder
aflatoxin
liver --> HCC
vinyl chloride
liver --> angiosarcoma
CCL4
liver-->centrilobular necrosis, fatty change
nitrosamines
stomach --> gastric cancer
cigarette smoke
larynx --> squamos cell carcinoma
lung --> squamos cell carcinoma
kidney --> renal cell carcinoma
bladder --> transitional cell carcinoma
asbestos
lung --> mesothelioma, bronchogenic carcinoma
arsenic
skin --> squamos cell carcinoma
liver --> angiosarcoma
naphthalene/aniline dyes
bladder --> transitional cell carcinoma
alkylating agents
blood --> leukemia
ACTH or ACTH like peptide
cushings sydnrome, small cell lung carcinoma
ADH
SIADH, small cell lung carcinoma/intracranial neoplasms
PTH related peptide, TGFB, TNF, IL-1
Hypercalcemia, Squamos cell lung carcinoma/renal cell carcinoma, pheochromocytoma
AB against presynaptic Ca+2 channels
Lambert Eaton syn, thymoma/small cell lung carcinoma
hyperuricemia due to excess nucleic acid turnover
gout/urate ephropathy, leukemias/lymphomas
benign epithelium
adenoma, papilloma
benign blood vessels
hemangioma
benign smooth muscles
leiomyoma
benign skeletal muscles
rhabdomyoma
benign connective tissue
fibroma
benign bone
osteoma
benign fat
lipoma
benign greater than 1 cell type
mature teratoma (in women)
malignant epithelium
adenocarcinoma, papillary carcinoma
malignant blood cells
leukemia, lymphoma
malignant blood vessels
angiosarcoma
malignant smooth muscles
leiomyosarcoma
malignant skeletal muscles
rhabdomyoscarcoma
malignant connective tissue
fibrosarcoma
malignant bone
osteosarcoma
malignant fat
liposarcoma
malignant greater than 1 cell type
mature teratoma (males), immature teratoma
hyperplasia
increase in number of cells, reversible
atrophy
decrease in size or number of cells
metaplasia
one adult cell replaced by another, reversible
dysplasia
change of size, shape, loss of cellular orientation, is preneoplastic, reversible
anaplasia
lack of differentiation, irreversible, does not resemble origin tissue
neoplasia
clonal proliferation of cells, uncontrolled
desmoplasia
fibrous tissue formation in response to neoplasm
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