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Phe to Tyr; BH4 cofactor & enzyme PAH; PKU disease = no PAH enzyme activity = build up of Phe in blood & Phenolic Pyruvate
Glucogenic & Ketogenic (5)
Ile, Thr, & Phenolic (Phe, Trp, Tyr); produce acetyl CoA or ketone bodies and cannot produce OAA which is necessary for gluconeogenesis
Val, Ile, Leu; greatest potential for E use in muscle; make up 25% of protein; Leu increases insulin; Ile forms hemoglobin; Val
BCAA Degradation Step 2
a-Keto groups undergo oxidative decarboxylation by a-keto acid dehydrogenase (Liver)
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