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13 terms

Neoplasia 6: Mutations: Anti-apoptosis genes

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What is the main ANTI APOPTOTIC GENE?
BCL-2 GENE
BCL-2 gene products normally ___________ by ___________
- prevents cell from undergoing apoptosis
- blocking the mitochondrial permeability transmembrane channels so that CYTOCHROME C won't leak out into the cytoplasm triggering APOPTOSIS
mutation of BCL-2 gene will cause _______ of the gene
OVER EXPRESSION of the gene
over-expression of the gene will lead to cells becoming _________
IMMORTAL
BCL-2 mutation is associated with
B cell follicular lymphoma
_______ causes over-expression of BCL-2 gene products --> ________
translocation t(14:18)
prevents apoptosis of B lymphocytes
MC malignant lymphoma
B cell follicular lymphoma
Burkitt's lymphoma
C-myc (protooncogene) - transcription
t(8;14)
CML - chronic myelogenous leukemia
ABL (protooncogene) - tyrosine kinase activity
t(9;22)
B Follicular Lymphoma
BCL2 (anti-apoptosis)
t(14;18)
Acute Promyelocytic leukemia
t(15;17)
Hodgkin's lymphoma is a cancer of the _________ cells
Reed S. cells
Non-Hodgkin's lymphoma arise from ___ and ____
B and C lymphocytes